Cargando…

NKp46‐specific single domain antibodies enable facile engineering of various potent NK cell engager formats

Herein, we describe the generation of potent NK cell engagers (NKCEs) based on single domain antibodies (sdAbs) specific for NKp46 harboring the humanized Fab version of Cetuximab for tumor targeting. After immunization of camelids, a plethora of different VHH domains were retrieved by yeast surface...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lipinski, Britta, Arras, Paul, Pekar, Lukas, Klewinghaus, Daniel, Boje, Ammelie Svea, Krah, Simon, Zimmermann, Jasmin, Klausz, Katja, Peipp, Matthias, Siegmund, Vanessa, Evers, Andreas, Zielonka, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2023
Materias:	Full‐length Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951198/ https://www.ncbi.nlm.nih.gov/pubmed/36775946 http://dx.doi.org/10.1002/pro.4593

Ejemplares similares

Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition
por: Lipinski, Britta, et al.
Publicado: (2023)

A library approach for the de novo high-throughput isolation of humanized VHH domains with favorable developability properties following camelid immunization
por: Arras, Paul, et al.
Publicado: (2023)

Milking the Cow: Cattle-Derived Chimeric Ultralong CDR-H3 Antibodies and Their Engineered CDR-H3-Only Knobbody Counterparts Targeting Epidermal Growth Factor Receptor Elicit Potent NK Cell-Mediated Cytotoxicity
por: Pekar, Lukas, et al.
Publicado: (2021)

Grabbing the Bull by Both Horns: Bovine Ultralong CDR-H3 Paratopes Enable Engineering of ‘Almost Natural’ Common Light Chain Bispecific Antibodies Suitable For Effector Cell Redirection
por: Klewinghaus, Daniel, et al.
Publicado: (2022)

HER2-specific immunoligands engaging NKp30 or NKp80 trigger NK-cell-mediated lysis of tumor cells and enhance antibody-dependent cell-mediated cytotoxicity
por: Peipp, Matthias, et al.
Publicado: (2015)

NKp46 Clusters at the Immune Synapse and Regulates NK Cell Polarization
por: Hadad, Uzi, et al.
Publicado: (2015)

Influenza A Virus Hemagglutinin and Other Pathogen Glycoprotein Interactions with NK Cell Natural Cytotoxicity Receptors NKp46, NKp44, and NKp30
por: Luczo, Jasmina M., et al.
Publicado: (2021)

NKp46 defines ovine cells that have characteristics corresponding to NK cells
por: Connelley, Timothy, et al.
Publicado: (2011)

NK Cell Receptor NKp46 Regulates Graft-versus-Host Disease
por: Ghadially, Hormas, et al.
Publicado: (2014)

Identification of New Antibodies Targeting Malignant Plasma Cells for Immunotherapy by Next-Generation Sequencing-Assisted Phage Display
por: Krohn, Steffen, et al.
Publicado: (2022)

Cattle-derived knob paratopes grafted onto peripheral loops of the IgG1 Fc region enable the generation of a novel symmetric bispecific antibody format
por: Yanakieva, Desislava, et al.
Publicado: (2023)

Increased NK cell immunity in a transgenic mouse model of NKp46 overexpression
por: Glasner, Ariella, et al.
Publicado: (2017)

Low NKp30, NKp46 and NKG2D expression and reduced cytotoxic activity on NK cells in cervical cancer and precursor lesions
por: Garcia-Iglesias, Trinidad, et al.
Publicado: (2009)

NKp46 regulates allergic responses
por: Ghadially, Hormas, et al.
Publicado: (2013)

Viral antigen mediated NKp46 activation of NK cells results in tumor rejection via NK-DC crosstalk
por: Chinnery, Fay, et al.
Publicado: (2012)

Evaluation of NKp46 expression and cytokine production of decidual NK cells in women with recurrent pregnancy loss
por: Yamamoto, Mayu, et al.
Publicado: (2022)

Altered NKp30, NKp46, NKG2D, and DNAM-1 Expression on Circulating NK Cells Is Associated with Tumor Progression in Human Gastric Cancer
por: Han, Bin, et al.
Publicado: (2018)

Modulation of NKp30- and NKp46-Mediated Natural Killer Cell Responses by Poxviral Hemagglutinin
por: Jarahian, Mostafa, et al.
Publicado: (2011)

Expression and function of NKp46 W32R: the human homologous protein of mouse NKp46 W32R (Noé)
por: Glasner, Ariella, et al.
Publicado: (2017)

Direct Recognition of Fusobacterium nucleatum by the NK Cell Natural Cytotoxicity Receptor NKp46 Aggravates Periodontal Disease
por: Chaushu, Stella, et al.
Publicado: (2012)

Porcine CD8α(dim/-)NKp46(high) NK cells are in a highly activated state
por: Mair, Kerstin H, et al.
Publicado: (2013)

NKp46 expression on NK cells as a prognostic and predictive biomarker for response to allo-SCT in patients with AML
por: Chretien, Anne-Sophie, et al.
Publicado: (2017)

A Blinded Investigation: Accentuated NK Lymphocyte CD335 (NKp46) Expression Predicts Pregnancy Failures
por: Dons’koi, Boris V., et al.
Publicado: (2023)

AI/ML combined with next-generation sequencing of VHH immune repertoires enables the rapid identification of de novo humanized and sequence-optimized single domain antibodies: a prospective case study
por: Arras, Paul, et al.
Publicado: (2023)

Derivation and Preclinical Characterization of CYT-303, a Novel NKp46-NK Cell Engager Targeting GPC3
por: Arulanandam, Antonio, et al.
Publicado: (2023)

Dual Fc optimization to increase the cytotoxic activity of a CD19-targeting antibody
por: Gehlert, Carina Lynn, et al.
Publicado: (2022)

Understanding the Synergy of NKp46 and Co-Activating Signals in Various NK Cell Subpopulations: Paving the Way for More Successful NK-Cell-Based Immunotherapy
por: Zamai, Loris, et al.
Publicado: (2020)

Dependence of innate lymphoid cell 1 development on NKp46
por: Wang, Yufeng, et al.
Publicado: (2018)

Altered NKp46 Recognition and Elimination of Influenza B Viruses
por: Duev-Cohen, Alexandra, et al.
Publicado: (2020)

Celiac Disease-Related Inflammation Is Marked by Reduction of Nkp44/Nkp46-Double Positive Natural Killer Cells
por: Marafini, Irene, et al.
Publicado: (2016)

The Murine Natural Cytotoxic Receptor NKp46/NCR1 Controls TRAIL Protein Expression in NK Cells and ILC1s
por: Sheppard, Sam, et al.
Publicado: (2018)

Porcine CD3(+)NKp46(+) Lymphocytes Have NK-Cell Characteristics and Are Present in Increased Frequencies in the Lungs of Influenza-Infected Animals
por: Mair, Kerstin H., et al.
Publicado: (2016)

Control of acute myeloid leukemia by a trifunctional NKp46-CD16a-NK cell engager targeting CD123
por: Gauthier, Laurent, et al.
Publicado: (2023)

P842: NOVEL MULTIFUNCTIONAL TETRAVALENT CD38 NKP46 FLEX-NK ENGAGERS ACTIVELY TARGET AND KILL MULTIPLE MYELOMA CELLS
por: Lin, L., et al.
Publicado: (2022)

Mapping of NKp46(+) Cells in Healthy Human Lymphoid and Non-Lymphoid Tissues
por: Tomasello, Elena, et al.
Publicado: (2012)

Unique and redundant functions of NKp46(+) ILC3s in models of intestinal inflammation
por: Song, Christina, et al.
Publicado: (2015)

WASH maintains NKp46(+) ILC3 cells by promoting AHR expression
por: Xia, Pengyan, et al.
Publicado: (2017)

Role of NKp46(+) natural killer cells in house dust mite‐driven asthma
por: Haspeslagh, Eline, et al.
Publicado: (2018)

Frequency and role of NKp46 and NKG2A in hepatitis B virus infection
por: Yoshioka, Teppei, et al.
Publicado: (2017)

Porcine Plasmacytoid Dendritic Cells Are Unique in Their Expression of a Functional NKp46 Receptor
por: Mair, Kerstin H., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3ua1kln8miu9crddc4jrnq6iia