Chemical Features of Polyanions Modulate Tau Aggregation and Conformational States

[Image: see text] The aggregation of tau into insoluble fibrils is a defining feature of neurodegenerative tauopathies. However, tau has a positive overall charge and is highly soluble; so, polyanions, such as heparin, are typically required to promote its aggregation in vitro. There are dozens of p...

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Detalles Bibliográficos
Autores principales: Montgomery, Kelly M., Carroll, Emma C., Thwin, Aye C., Quddus, Athena Y., Hodges, Paige, Southworth, Daniel R., Gestwicki, Jason E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951223/
https://www.ncbi.nlm.nih.gov/pubmed/36753572
http://dx.doi.org/10.1021/jacs.2c08004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951223/
https://www.ncbi.nlm.nih.gov/pubmed/36753572
http://dx.doi.org/10.1021/jacs.2c08004

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