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Chemical Features of Polyanions Modulate Tau Aggregation and Conformational States
[Image: see text] The aggregation of tau into insoluble fibrils is a defining feature of neurodegenerative tauopathies. However, tau has a positive overall charge and is highly soluble; so, polyanions, such as heparin, are typically required to promote its aggregation in vitro. There are dozens of p...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951223/ https://www.ncbi.nlm.nih.gov/pubmed/36753572 http://dx.doi.org/10.1021/jacs.2c08004 |