Cargando…

The emerging role of MCPH1/BRIT1 in carcinogenesis

The MCPH1 gene, also known as BRCT-repeat inhibitor of hTERT expression (BRIT1), has three BRCA1 carboxyl-terminal domains which is an important regulator of DNA repair, cell cycle checkpoints and chromosome condensation. MCPH1/BRIT1 is also known as a tumour suppressor in different types of human c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alsolami, Mona, Aboalola, Doaa, Malibari, Dolal, Alghamdi, Tariq, Alshekhi, Walaa, Jad, Hind, Rumbold-Hall, Rea, Altowairqi, Ahlam S., Bell, Sandra M., Alsiary, Rawiah Abdullah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951231/ https://www.ncbi.nlm.nih.gov/pubmed/36845691 http://dx.doi.org/10.3389/fonc.2023.1047588

Ejemplares similares

Early-Onset Colorectal Cancer Survival among Unscreened Population -Multicenter Cohort Retrospective Analysis
por: Alsiary, Rawiah, et al.
Publicado: (2023)

BRIT1/MCPH1 Links Chromatin Remodeling to DNA Damage Response
por: Peng, Guang, et al.
Publicado: (2009)

Mortality‐to‐incidence ratio of early‐onset colorectal cancer in high‐income Asian and Middle Eastern countries: A systemic analysis of the Global Burden of Diseases Study 2019
por: Ramadan, Majed, et al.
Publicado: (2023)

Multiple Roles of BRIT1/MCPH1 in DNA Damage Response, DNA Repair, and Cancer Suppression
por: Lin, Shiaw-Yih, et al.
Publicado: (2010)

Mcph1/Brit1 deficiency promotes genomic instability and tumor formation in a mouse model
por: Liang, Yulong, et al.
Publicado: (2014)

The UBC Domain Is Required for BRUCE to Promote BRIT1/MCPH1 Function in DSB Signaling and Repair Post Formation of BRUCE-USP8-BRIT1 Complex
por: Ge, Chunmin, et al.
Publicado: (2015)

An Infodemic of Misinformation on Stem Cell Therapy Among the Population of Saudi Arabia: A Cross-Sectional Study
por: Aboalola, Doaa, et al.
Publicado: (2022)

BRIT1/MCPH1 Is Essential for Mitotic and Meiotic Recombination DNA Repair and Maintaining Genomic Stability in Mice
por: Liang, Yulong, et al.
Publicado: (2010)

Mcph1-Deficient Mice Reveal a Role for MCPH1 in Otitis Media
por: Chen, Jing, et al.
Publicado: (2013)

Correction: Mcph1-Deficient Mice Reveal a Role for MCPH1 in Otitis Media
por: Chen, Jing, et al.
Publicado: (2013)

A Novel MCPH1 Isoform Complements the Defective Chromosome Condensation of Human MCPH1-Deficient Cells
por: Gavvovidis, Ioannis, et al.
Publicado: (2012)

Phenotypes in siblings with homozygous mutations of TRAPPC9 and/or MCPH1 support a bifunctional model of MCPH1
por: Duerinckx, Sarah, et al.
Publicado: (2018)

Brits bellenvat voor Europese kernfysici
Publicado: (1964)

Budget Brits hunt secrets of universe
Publicado: (2009)

MCPH1 keeps chromosomes strung out
por: Leslie, Mitch
Publicado: (2011)

Multifaceted Microcephaly-Related Gene MCPH1
por: Kristofova, Martina, et al.
Publicado: (2022)

Silencing BRIT1 Facilitates the Abilities of Invasiveness and Migration in Trophoblast Cells
por: Liu, Luping, et al.
Publicado: (2018)

Lockdown forces Brits to become 'DIY dentists'
Publicado: (2021)

MCPH1: a window into brain development and evolution
por: Pulvers, Jeremy N., et al.
Publicado: (2015)

Identification of Pathogenic Mutations in Primary Microcephaly- (MCPH-) Related Three Genes CENPJ, CASK, and MCPH1 in Consanguineous Pakistani Families
por: Khan, Niaz Muhammad, et al.
Publicado: (2022)

Reduced MCPH1 expression in breast cancer and response to chemotherapy
por: Richardson, J, et al.
Publicado: (2010)

MCPH1, a potential predictor for response to cancer chemotherapy
por: Bell, SM, et al.
Publicado: (2008)

MCPH1, beyond its role deciding the brain size
por: Kristofova, Martina, et al.
Publicado: (2021)

Week in Review: How a Brit set the web free
Publicado: (2009)

Overexpression of MCPH1 inhibits the migration and invasion of lung cancer cells
por: Wu, Xiaobin, et al.
Publicado: (2018)

Microcephaly family protein MCPH1 stabilizes RAD51 filaments
por: Chang, Hao-Yen, et al.
Publicado: (2020)

MCPH1: A Novel Case Report and a Review of the Literature
por: Caraffi, Stefano Giuseppe, et al.
Publicado: (2022)

Phylogeny and adaptive evolution of the brain-development gene microcephalin (MCPH1) in cetaceans
por: McGowen, Michael R, et al.
Publicado: (2011)

The Central Domain of MCPH1 Controls Development of the Cerebral Cortex and Gonads in Mice
por: Wang, Yaru, et al.
Publicado: (2022)

Meet the Brit couple who's 'Big Bang' beneath the sheets actually worked!
Publicado: (2008)

CMA analysis identifies homozygous deletion of MCPH1 in 2 brothers with primary Microcephaly-1
por: Hemmat, Morteza, et al.
Publicado: (2017)

MCPH1 regulates chromosome condensation and shaping as a composite modulator of condensin II
por: Yamashita, Daisuke, et al.
Publicado: (2011)

MCPH1, mutated in primary microcephaly, is required for efficient chromosome alignment during mitosis
por: Arroyo, M., et al.
Publicado: (2017)

The N-terminal BRCT domain determines MCPH1 function in brain development and fertility
por: Liu, Xiaoqian, et al.
Publicado: (2021)

Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly
por: Cicconi, Alessandro, et al.
Publicado: (2020)

Prenatal Identification of a Novel Mutation in the MCPH1 Gene Associated with Autosomal Recessive Primary Microcephaly (MCPH) Using Next Generation Sequencing (NGS): A Case Report and Review of the Literature
por: Papoulidis, Ioannis, et al.
Publicado: (2022)

Different Effects of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor-2 on Myogenic Differentiation of Human Mesenchymal Stem Cells
por: Aboalola, Doaa, et al.
Publicado: (2017)

Establishment of a Mouse Model with Misregulated Chromosome Condensation due to Defective Mcph1 Function
por: Trimborn, Marc, et al.
Publicado: (2010)

Novel compound heterozygous mutations in MCPH1 gene causes primary microcephaly in Saudi family
por: Naseer, Muhammad I., et al.
Publicado: (2018)

pBRIT: gene prioritization by correlating functional and phenotypic annotations through integrative data fusion
por: Kumar, Ajay Anand, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_f9ohqeepairus18lf279o82euu