Mutant KRAS Drives Immune Evasion by Sensitizing Cytotoxic T‐Cells to Activation‐Induced Cell Death in Colorectal Cancer

The roles of oncogenic KRAS in tumor immune evasion remain poorly understood. Here, mutant KRAS is identified as a key driver of tumor immune evasion in colorectal cancer (CRC). In human CRC specimens, a significant reduction in cytotoxic CD8(+) T‐cell tumor infiltration is found in patients with mu...

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Detalles Bibliográficos
Autores principales: Liu, Huashan, Liang, Zhenxing, Cheng, Sijing, Huang, Liang, Li, Wenxin, Zhou, Chi, Zheng, Xiaobin, Li, Shujuan, Zeng, Ziwei, Kang, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951350/
https://www.ncbi.nlm.nih.gov/pubmed/36599679
http://dx.doi.org/10.1002/advs.202203757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951350/
https://www.ncbi.nlm.nih.gov/pubmed/36599679
http://dx.doi.org/10.1002/advs.202203757

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