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Large-scale in vitro microdosimetry via live cell microscopy imaging: implications for radiosensitivity and RBE evaluations in alpha-emitter radiopharmaceutical therapy

BACKGROUND: Alpha-emitter radiopharmaceutical therapy (αRPT) has shown promising outcomes in metastatic disease. However, the short range of the alpha particles necessitates dosimetry on a near-cellular spatial scale. Current knowledge on cellular dosimetry is primarily based on in vitro experiments...

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Detalles Bibliográficos
Autores principales: Bastiaannet, Remco, Liatsou, Ioanna, F Hobbs, Robert, Sgouros, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951424/
https://www.ncbi.nlm.nih.gov/pubmed/36829143
http://dx.doi.org/10.1186/s12967-023-03991-1