Myeloid deficiency of the intrinsic clock protein BMAL1 accelerates cognitive aging by disrupting microglial synaptic pruning

Aging is associated with loss of circadian immune responses and circadian gene transcription in peripheral macrophages. Microglia, the resident macrophages of the brain, also show diurnal rhythmicity in regulating local immune responses and synaptic remodeling. To investigate the interaction between...

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Detalles Bibliográficos
Autores principales: Iweka, Chinyere Agbaegbu, Seigneur, Erica, Hernandez, Amira Latif, Paredes, Sur Herrera, Cabrera, Mica, Blacher, Eran, Pasternak, Connie Tsai, Longo, Frank M., de Lecea, Luis, Andreasson, Katrin I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951430/
https://www.ncbi.nlm.nih.gov/pubmed/36829230
http://dx.doi.org/10.1186/s12974-023-02727-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951430/
https://www.ncbi.nlm.nih.gov/pubmed/36829230
http://dx.doi.org/10.1186/s12974-023-02727-8

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