Cargando…

Myeloid deficiency of the intrinsic clock protein BMAL1 accelerates cognitive aging by disrupting microglial synaptic pruning

Aging is associated with loss of circadian immune responses and circadian gene transcription in peripheral macrophages. Microglia, the resident macrophages of the brain, also show diurnal rhythmicity in regulating local immune responses and synaptic remodeling. To investigate the interaction between...

Descripción completa

Detalles Bibliográficos
Autores principales:	Iweka, Chinyere Agbaegbu, Seigneur, Erica, Hernandez, Amira Latif, Paredes, Sur Herrera, Cabrera, Mica, Blacher, Eran, Pasternak, Connie Tsai, Longo, Frank M., de Lecea, Luis, Andreasson, Katrin I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951430/ https://www.ncbi.nlm.nih.gov/pubmed/36829230 http://dx.doi.org/10.1186/s12974-023-02727-8

Ejemplares similares

Deficiency of the Circadian Clock Gene Bmal1 Reduces Microglial Immunometabolism
por: Wang, Xiao-Lan, et al.
Publicado: (2020)

Regulation of circadian clock transcriptional output by CLOCK:BMAL1
por: Trott, Alexandra J., et al.
Publicado: (2018)

Disruption of the Clock Components CLOCK and BMAL1 Leads to Hypoinsulinemia and Diabetes
por: Marcheva, Biliana, et al.
Publicado: (2010)

Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration
por: Ding, Xin, et al.
Publicado: (2021)

Microglial Pruning: Relevance for Synaptic Dysfunction in Multiple Sclerosis and Related Experimental Models
por: Geloso, Maria Concetta, et al.
Publicado: (2021)

Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK
por: Langmesser, Sonja, et al.
Publicado: (2008)

Microglial Activation – Tuning and Pruning Adult Neurogenesis
por: Ekdahl, Christine T.
Publicado: (2012)

Deficiency of the clock gene Bmal1 affects neural progenitor cell migration
por: Ali, Amira A. H., et al.
Publicado: (2018)

The aging clock: to ‘BMAL'icious toward learning and memory
por: Gerstner, Jason R.
Publicado: (2010)

BMAL1 dephosphorylation determines the pace of the circadian clock
por: Schibler, Ueli
Publicado: (2021)

RAE1 promotes BMAL1 shuttling and regulates degradation and activity of CLOCK: BMAL1 heterodimer
por: Zheng, Xulei, et al.
Publicado: (2019)

BMAL1 and CLOCK, Two Essential Components of the Circadian Clock, Are Involved in Glucose Homeostasis
por: Rudic, R. Daniel, et al.
Publicado: (2004)

CLOCK:BMAL1 is a pioneer-like transcription factor
por: Menet, Jerome S., et al.
Publicado: (2014)

Opposite Carcinogenic Effects of Circadian Clock Gene BMAL1
por: Korkmaz, Tuba, et al.
Publicado: (2018)

The Circadian Clock Gene BMAL1 Coordinates Intestinal Regeneration
por: Stokes, Kyle, et al.
Publicado: (2017)

The circadian clock component BMAL1 regulates osteogenesis in osseointegration
por: Deng, Shiyong, et al.
Publicado: (2022)

Protein phosphatase 4 controls circadian clock dynamics by modulating CLOCK/BMAL1 activity
por: Klemz, Sabrina, et al.
Publicado: (2021)

Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids
por: Umemura, Yasuhiro, et al.
Publicado: (2021)

Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice
por: Monsorno, Katia, et al.
Publicado: (2023)

Cryptochrome and Period Proteins Are Regulated by the CLOCK/BMAL1 Gene: Crosstalk between the PPARs/RXR [Formula: see text]-Regulated and CLOCK/BMAL1-Regulated Systems
por: Nakamura, Koh-ichi, et al.
Publicado: (2008)

Effects of BMAL1 Manipulation on the Brain’s Master Circadian Clock and Behavior
por: Haque, Samreen N., et al.
Publicado: (2019)

Association of BMAL1 clock gene polymorphisms with fasting glucose in children
por: Yang, Yi-De, et al.
Publicado: (2023)

Microglial trogocytosis and the complement system regulate axonal pruning in vivo
por: Lim, Tony KY, et al.
Publicado: (2021)

Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock
por: Ye, Rui, et al.
Publicado: (2014)

Circadian clock gene Clock-Bmal1 regulates cellular senescence in Chronic obstructive pulmonary disease
por: Li, Lingling, et al.
Publicado: (2022)

Microglial synaptic pruning in the nucleus accumbens during adolescence sex-specifically influences splenic immune outcomes
por: Kirkland, J. M., et al.
Publicado: (2023)

NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1
por: Shen, Yang, et al.
Publicado: (2021)

Nuclear envelope protein MAN1 regulates clock through BMAL1
por: Lin, Shu-Ting, et al.
Publicado: (2014)

BMAL1 LINKS THE CIRCADIAN CLOCK TO VIRAL AIRWAY PATHOLOGY AND ASTHMA PHENOTYPES
por: Ehlers, Anna, et al.
Publicado: (2017)

Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis
por: Lavtar, Polona, et al.
Publicado: (2018)

Translational Regulation of Clock Genes BMAL1 and REV-ERBα by Polyamines
por: Sakamoto, Akihiko, et al.
Publicado: (2021)

REGγ regulates circadian clock by modulating BMAL1 protein stability
por: Kubra, Syeda, et al.
Publicado: (2021)

Circadian Clock Component BMAL1 in the Paraventricular Nucleus Regulates Glucose Metabolism
por: Nakata, Masanori, et al.
Publicado: (2021)

Emerging Insight Into the Role of Circadian Clock Gene BMAL1 in Cellular Senescence
por: Zhang, Wenqian, et al.
Publicado: (2022)

Polymorphisms in ARNTL/BMAL1 and CLOCK Are Not Associated with Multiple Sclerosis in Spanish Population
por: de Rojas, Isabel, et al.
Publicado: (2022)

Impact of Targeted Deletion of the Circadian Clock Gene Bmal1 in Excitatory Forebrain Neurons on Adult Neurogenesis and Olfactory Function
por: Ali, Amira A. H., et al.
Publicado: (2020)

Cytoplasmic-predominant Pten increases microglial activation and synaptic pruning in a murine model with autism-like phenotype
por: Sarn, Nicholas, et al.
Publicado: (2020)

“Defining the Independence of the Liver Circadian Clock” & “BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis”
por: Rotinen, Mirja
Publicado: (2020)

Ketamine Influences CLOCK:BMAL1 Function Leading to Altered Circadian Gene Expression
por: Bellet, Marina M., et al.
Publicado: (2011)

Effect of Resveratrol, a SIRT1 Activator, on the Interactions of the CLOCK/BMAL1 Complex
por: Park, Insung, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_j5euuk130c4kp7p328qp5o0dai