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Does multi-way, long-range chromatin contact data advance 3D genome reconstruction?

BACKGROUND: Methods for inferring the three-dimensional (3D) configuration of chromatin from conformation capture assays that provide strictly pairwise interactions, notably Hi-C, utilize the attendant contact matrix as input. More recent assays, in particular split-pool recognition of interactions...

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Detalles Bibliográficos
Autores principales: Olshen, Adam B., Segal, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951495/
https://www.ncbi.nlm.nih.gov/pubmed/36829114
http://dx.doi.org/10.1186/s12859-023-05170-x