DIMPLE: deep insertion, deletion, and missense mutation libraries for exploring protein variation in evolution, disease, and biology

Insertions and deletions (indels) enable evolution and cause disease. Due to technical challenges, indels are left out of most mutational scans, limiting our understanding of them in disease, biology, and evolution. We develop a low cost and bias method, DIMPLE, for systematically generating deletio...

Descripción completa

Detalles Bibliográficos
Autores principales: Macdonald, Christian B., Nedrud, David, Grimes, Patrick Rockefeller, Trinidad, Donovan, Fraser, James S., Coyote-Maestas, Willow
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951526/
https://www.ncbi.nlm.nih.gov/pubmed/36829241
http://dx.doi.org/10.1186/s13059-023-02880-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951526/
https://www.ncbi.nlm.nih.gov/pubmed/36829241
http://dx.doi.org/10.1186/s13059-023-02880-6

Ejemplares similares