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Whole‐Cell P450 Biocatalysis Using Engineered Escherichia coli with Fine‐Tuned Heme Biosynthesis

By exploiting versatile P450 enzymes, whole‐cell biocatalysis can be performed to synthesize valuable compounds in Escherichia coli. However, the insufficient supply of heme limits the whole‐cell P450 biocatalytic activity. Here a strategy for improving intracellular heme biosynthesis to enhance the...

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Detalles Bibliográficos
Autores principales: Hu, Baodong, Yu, Haibo, Zhou, Jingwen, Li, Jianghua, Chen, Jian, Du, Guocheng, Lee, Sang Yup, Zhao, Xinrui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951570/
https://www.ncbi.nlm.nih.gov/pubmed/36526588
http://dx.doi.org/10.1002/advs.202205580