Manipulation of diacylglycerol and ERK-mediated signaling differentially controls CD8(+) T cell responses during chronic viral infection

INTRODUCTION: Activation of T cell receptor (TCR) signaling is critical for clonal expansion of CD8+ T cells. However, the effects of augmenting TCR signaling during chronic antigen exposure is less understood. Here, we investigated the role of diacylglycerol (DAG)-mediated signaling downstream of t...

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Detalles Bibliográficos
Autores principales: Harabuchi, Shohei, Khan, Omar, Bassiri, Hamid, Yoshida, Taku, Okada, Yohei, Takizawa, Masaomi, Ikeda, Osamu, Katada, Akihiro, Kambayashi, Taku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951774/
https://www.ncbi.nlm.nih.gov/pubmed/36846018
http://dx.doi.org/10.3389/fimmu.2022.1032113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951774/
https://www.ncbi.nlm.nih.gov/pubmed/36846018
http://dx.doi.org/10.3389/fimmu.2022.1032113

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