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In silico screening of Andrographis paniculata secondary metabolites as anti-diabetes mellitus through PDE9 inhibition

BACKGROUND AND PURPOSE: Andrographis paniculata (AP) has long been used as an anti-diabetic agent, but the mechanism of action and active substance responsible for the anti-diabetic effect, particularly by inhibiting phosphodiesterase-9 (PDE9), which is one of the targets of anti-diabetic medication...

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Detalles Bibliográficos
Autores principales: Ischak, Netty Ino, Aman, La Ode, Hasan, Hamsidar, Kilo, Akram La, Asnawi, Aiyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951786/
https://www.ncbi.nlm.nih.gov/pubmed/36846729
http://dx.doi.org/10.4103/1735-5362.363616