Investigation of α,ω-Disubstituted Polyamine-Cholic Acid Conjugates Identifies Hyodeoxycholic and Chenodeoxycholic Scaffolds as Non-Toxic, Potent Antimicrobials

With the increased incidence of antibiotic resistance, the discovery and development of new antibacterials is of increasing importance and urgency. The report of the natural product antibiotic squalamine in 1993 has stimulated a lot of interest in the study of structurally simplified cholic acid-pol...

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Detalles Bibliográficos
Autores principales: Sue, Kenneth, Cadelis, Melissa M., Troia, Thomas, Rouvier, Florent, Bourguet-Kondracki, Marie-Lise, Brunel, Jean Michel, Copp, Brent R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951859/
https://www.ncbi.nlm.nih.gov/pubmed/36830315
http://dx.doi.org/10.3390/antibiotics12020404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951859/
https://www.ncbi.nlm.nih.gov/pubmed/36830315
http://dx.doi.org/10.3390/antibiotics12020404

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