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Fragment-Based Lead Discovery Strategies in Antimicrobial Drug Discovery
Fragment-based lead discovery (FBLD) is a powerful application for developing ligands as modulators of disease targets. This approach strategy involves identification of interactions between low-molecular weight compounds (100–300 Da) and their putative targets, often with low affinity (K(D) ~0.1–1...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9951956/ https://www.ncbi.nlm.nih.gov/pubmed/36830226 http://dx.doi.org/10.3390/antibiotics12020315 |