Oscillatory ERK Signaling and Morphology Determine Heterogeneity of Breast Cancer Cell Chemotaxis via MEK-ERK and p38-MAPK Signaling Pathways

Chemotaxis, regulated by oscillatory signals, drives critical processes in cancer metastasis. Crucial chemoattractant molecules in breast cancer, CXCL12 and EGF, drive the activation of ERK and Akt. Regulated by feedback and crosstalk mechanisms, oscillatory signals in ERK and Akt control resultant...

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Detalles Bibliográficos
Autores principales: Ho, Kenneth K. Y., Srivastava, Siddhartha, Kinnunen, Patrick C., Garikipati, Krishna, Luker, Gary D., Luker, Kathryn E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952091/
https://www.ncbi.nlm.nih.gov/pubmed/36829763
http://dx.doi.org/10.3390/bioengineering10020269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952091/
https://www.ncbi.nlm.nih.gov/pubmed/36829763
http://dx.doi.org/10.3390/bioengineering10020269

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