Cargando…

Failure to Thrive: Impaired BDNF Transport along the Cortical–Striatal Axis in Mouse Q140 Neurons of Huntington’s Disease

SIMPLE SUMMARY: The brain-derived neurotrophic factor (BDNF) is implicated in the function and survival of striatal neurons. Deficits in neurotrophic support by BDNF have been hypothesized to contribute to the neurodegeneration of striatal neurons in Huntington’s disease (HD). This article outlines...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maloney, Michael T., Wang, Wei, Bhowmick, Sumana, Millan, Ivan, Kapur, Mridu, Herrera, Nicolas, Frost, Everett, Zhang, Elena Y., Song, Scott, Wang, Melissa, Park, Amelia Bora, Yao, Annabelle Y., Yang, Yanmin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952218/ https://www.ncbi.nlm.nih.gov/pubmed/36829435 http://dx.doi.org/10.3390/biology12020157

Ejemplares similares

Huntington’s Disease and Striatal Signaling
por: Roze, Emmanuel, et al.
Publicado: (2011)

Differential loss of thalamostriatal and corticostriatal input to striatal projection neuron types prior to overt motor symptoms in the Q140 knock-in mouse model of Huntington's disease
por: Deng, Yun-Ping, et al.
Publicado: (2014)

ESC-Derived BDNF-Overexpressing Neural Progenitors Differentially Promote Recovery in Huntington's Disease Models by Enhanced Striatal Differentiation
por: Zimmermann, Tina, et al.
Publicado: (2016)

Cortical and Striatal Circuits in Huntington’s Disease
por: Blumenstock, Sonja, et al.
Publicado: (2020)

Striatal network modeling in Huntington’s Disease
por: Ponzi, Adam, et al.
Publicado: (2020)

BDNF signaling and survival of striatal neurons
por: Baydyuk, Maryna, et al.
Publicado: (2014)

Proteostasis in striatal cells and selective neurodegeneration in Huntington’s disease
por: Margulis, Julia, et al.
Publicado: (2014)

The mechanism of degeneration of striatal neuronal subtypes in Huntington disease
por: Rikani, Azadeh A., et al.
Publicado: (2014)

Striatal Vulnerability in Huntington’s Disease: Neuroprotection Versus Neurotoxicity
por: Morigaki, Ryoma, et al.
Publicado: (2017)

Striatal Network Models of Huntington's Disease Dysfunction Phenotypes
por: Zheng, Pengsheng, et al.
Publicado: (2017)

Impaired TrkB Signaling Underlies Reduced BDNF-Mediated Trophic Support of Striatal Neurons in the R6/2 Mouse Model of Huntington’s Disease
por: Nguyen, Khanh Q., et al.
Publicado: (2016)

The Clp1 R140H mutation alters tRNA metabolism and mRNA 3′ processing in mouse models of pontocerebellar hypoplasia
por: Monaghan, Caitlin E., et al.
Publicado: (2021)

The Utility of BDNF Detection in Assessing Severity of Huntington’s Disease
por: Plinta, Klaudia, et al.
Publicado: (2021)

Striatal parvalbuminergic neurons are lost in Huntington's disease: implications for dystonia
por: Reiner, Anton, et al.
Publicado: (2013)

Striatal Interneurons in Transgenic Nonhuman Primate Model of Huntington’s Disease
por: Lallani, Shoeb B., et al.
Publicado: (2019)

Dual tasking impairments are associated with striatal pathology in Huntington’s disease
por: Lo, Johnny, et al.
Publicado: (2020)

Fetal striatal grafting slows motor and cognitive decline of Huntington's disease
por: Paganini, Marco, et al.
Publicado: (2014)

VGF and striatal cell damage in in vitro and in vivo models of Huntington’s disease
por: Noda, Yasuhiro, et al.
Publicado: (2015)

Preserving cortico-striatal function: deep brain stimulation in Huntington’s disease
por: Nagel, Sean J., et al.
Publicado: (2015)

Functional connectivity modeling of consistent cortico-striatal degeneration in Huntington's disease
por: Dogan, Imis, et al.
Publicado: (2015)

Striatal Neurodegeneration that Mimics Huntington’s Disease Modifies GABA-induced Currents
por: Flores-Hernández, Jorge, et al.
Publicado: (2018)

Altered enhancer transcription underlies Huntington’s disease striatal transcriptional signature
por: Le Gras, Stéphanie, et al.
Publicado: (2017)

Rate of torque development and striatal shape in individuals with prodromal Huntington's disease
por: Cruickshank, Travis, et al.
Publicado: (2020)

Diminished LC3-Associated Phagocytosis by Huntington’s Disease Striatal Astrocytes
por: Wakida, Nicole M., et al.
Publicado: (2022)

Transcriptional vulnerabilities of striatal neurons in human and rodent models of Huntington’s disease
por: Matsushima, Ayano, et al.
Publicado: (2023)

Striatal Afferent BDNF Is Disrupted by Synucleinopathy and Partially Restored by STN DBS
por: Miller, Kathryn M., et al.
Publicado: (2021)

Striatal Pre-Enkephalin Overexpression Improves Huntington’s Disease Symptoms in the R6/2 Mouse Model of Huntington’s Disease
por: Bissonnette, Stéphanie, et al.
Publicado: (2013)

In Silico Protein Folding Prediction of COVID-19 Mutations and Variants
por: Bhowmick, Sumana, et al.
Publicado: (2022)

Nemitin, a Novel Map8/Map1s Interacting Protein with Wd40 Repeats
por: Wang, Wei, et al.
Publicado: (2012)

No association between polymorphisms in the BDNF gene and age at onset in Huntington disease
por: Mai, Maren, et al.
Publicado: (2006)

Localization of BDNF mRNA with the Huntington's disease protein in rat brain
por: Ma, Bin, et al.
Publicado: (2010)

Functional analysis of brain derived neurotrophic factor (BDNF) in Huntington’s disease
por: Zhou, Zhike, et al.
Publicado: (2021)

A Role for Oxidized DNA Precursors in Huntington's Disease–Like Striatal Neurodegeneration
por: De Luca, Gabriele, et al.
Publicado: (2008)

Nuclear translocation of AMPK-α1 potentiates striatal neurodegeneration in Huntington’s disease
por: Ju, Tz-Chuen, et al.
Publicado: (2011)

Environment-dependent striatal gene expression in the BACHD rat model for Huntington disease
por: Novati, Arianna, et al.
Publicado: (2018)

White matter cortico-striatal tracts predict apathy subtypes in Huntington's disease
por: De Paepe, Audrey E., et al.
Publicado: (2019)

Angiotensins and Huntington’s Disease: A Study on Immortalized Progenitor Striatal Cell Lines
por: De Mello, Walmor C., et al.
Publicado: (2017)

Changes in striatal activity and functional connectivity in a mouse model of Huntington's disease
por: Cabanas, Magali, et al.
Publicado: (2017)

Reduced Fractalkine Levels Lead to Striatal Synaptic Plasticity Deficits in Huntington’s Disease
por: Kim, Anya, et al.
Publicado: (2020)

Deficits in coordinated neuronal activity and network topology are striatal hallmarks in Huntington’s disease
por: Fernández-García, S., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_jan9qbvqn33latmc1t0rhndslq