Inside the Mechanism of Action of Three Pyrazole Derivatives in Human Platelets and Endothelial Cells

In the effort to obtain multitarget compound interfering with inflammation, oxidative stress, and tumorigenesis, we synthesized a small library of pyrazole compounds, selecting 4a, 4f, and 4g as the most noteworthy being IC(50) against platelet ROS production induced by thrombin of about 10 µM. The...

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Detalles Bibliográficos
Autores principales: Brullo, Chiara, Russo, Eleonora, Garibaldi, Silvano, Altieri, Paola, Ameri, Pietro, Ravera, Silvia, Signorello, Maria Grazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952262/
https://www.ncbi.nlm.nih.gov/pubmed/36829775
http://dx.doi.org/10.3390/antiox12020216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952262/
https://www.ncbi.nlm.nih.gov/pubmed/36829775
http://dx.doi.org/10.3390/antiox12020216

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