Effects of Pyruvate Kinase M2 (PKM2) Gene Deletion on Astrocyte-Specific Glycolysis and Global Cerebral Ischemia-Induced Neuronal Death

Ischemic stroke is caused by insufficient blood flow to the brain. Astrocytes have a role in bidirectionally converting pyruvate, generated via glycolysis, into lactate and then supplying it to neurons through astrocyte–neuron lactate shuttle (ANLS). Pyruvate kinase M2 (PKM2) is an enzyme that depho...

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Detalles Bibliográficos
Autores principales: Kang, Beom-Seok, Choi, Bo-Young, Kho, A-Ra, Lee, Song-Hee, Hong, Dae-Ki, Park, Min-Kyu, Lee, Si-Hyun, Lee, Chang-Juhn, Yang, Hyeun-Wook, Woo, Seo-Young, Park, Se-Wan, Kim, Dong-Yeon, Park, Jae-Bong, Chung, Won-Suk, Suh, Sang-Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952809/
https://www.ncbi.nlm.nih.gov/pubmed/36830049
http://dx.doi.org/10.3390/antiox12020491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952809/
https://www.ncbi.nlm.nih.gov/pubmed/36830049
http://dx.doi.org/10.3390/antiox12020491

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