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The Anti-Aging Hormone Klotho Promotes Retinal Pigment Epithelium Cell Viability and Metabolism by Activating the AMPK/PGC-1α Pathway
Initially discovered by Makuto Kuro-o in 1997, Klotho is a putative aging-suppressor gene when overexpressed and accelerates aging when deleted in mice. Previously, we showed that α-Klotho regulates retinal pigment epithelium (RPE) functions and protects against oxidative stress. However, the mechan...
Autores principales: | Zhou, Shuyan, Hum, Jacob, Taskintuna, Kaan, Olaya, Stephanie, Steinman, Jeremy, Ma, Junfeng, Golestaneh, Nady |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952846/ https://www.ncbi.nlm.nih.gov/pubmed/36829944 http://dx.doi.org/10.3390/antiox12020385 |
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