Cargando…

A New Insight into MYC Action: Control of RNA Polymerase II Methylation and Transcription Termination

MYC oncoprotein deregulation is a common catastrophic event in human cancer and limiting its activity restrains tumor development and maintenance, as clearly shown via Omomyc, an MYC-interfering 90 amino acid mini-protein. MYC is a multifunctional transcription factor that regulates many aspects of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Scagnoli, Fiorella, Palma, Alessandro, Favia, Annarita, Scuoppo, Claudio, Illi, Barbara, Nasi, Sergio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952900/ https://www.ncbi.nlm.nih.gov/pubmed/36830948 http://dx.doi.org/10.3390/biomedicines11020412

Ejemplares similares

The “Superoncogene” Myc at the Crossroad between Metabolism and Gene Expression in Glioblastoma Multiforme
por: Cencioni, Chiara, et al.
Publicado: (2023)

The Protein Arginine Methyltransferases 1 and 5 affect Myc properties in glioblastoma stem cells
por: Favia, Annarita, et al.
Publicado: (2019)

Myc and Omomyc functionally associate with the Protein Arginine Methyltransferase 5 (PRMT5) in glioblastoma cells
por: Mongiardi, Maria Patrizia, et al.
Publicado: (2015)

Myc beyond Cancer: Regulation of Mammalian Tissue Regeneration
por: Illi, Barbara, et al.
Publicado: (2023)

Copper/MYC/CTR1 interplay: a dangerous relationship in hepatocellular carcinoma
por: Porcu, Cristiana, et al.
Publicado: (2018)

c-MYC inhibition impairs hypoxia response in glioblastoma multiforme
por: Mongiardi, Maria Patrizia, et al.
Publicado: (2016)

The Action Mechanism of the Myc Inhibitor Termed Omomyc May Give Clues on How to Target Myc for Cancer Therapy
por: Savino, Mauro, et al.
Publicado: (2011)

Integrative analysis of RNA polymerase II and transcriptional dynamics upon MYC activation
por: de Pretis, Stefano, et al.
Publicado: (2017)

Disengaging polymerase: Terminating RNA polymerase II transcription in budding yeast()
por: Mischo, Hannah E., et al.
Publicado: (2013)

Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine
por: Hou, Haifeng, et al.
Publicado: (2021)

An integrated model for termination of RNA polymerase III transcription
por: Xie, Juanjuan, et al.
Publicado: (2022)

Dynamic transitions in RNA polymerase II density profiles during transcription termination
por: Grosso, Ana Rita, et al.
Publicado: (2012)

A common functional consequence of tumor-derived mutations within c-MYC
por: Chakraborty, Abhishek A., et al.
Publicado: (2014)

Cooperative interaction of transcription termination factors with the RNA polymerase II C-terminal domain
por: Lunde, Bradley M., et al.
Publicado: (2010)

MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation
por: Baluapuri, Apoorva, et al.
Publicado: (2019)

Molecular Dissection of Mammalian RNA Polymerase II Transcriptional Termination
por: West, Steven, et al.
Publicado: (2008)

Recent advances in understanding transcription termination by RNA polymerase II
por: Loya, Travis J., et al.
Publicado: (2016)

Engineering efficient termination of bacteriophage T7 RNA polymerase transcription
por: Calvopina-Chavez, Diana G, et al.
Publicado: (2022)

Delineation of the Exact Transcription Termination Signal for Type 3 Polymerase III
por: Gao, Zongliang, et al.
Publicado: (2017)

An end in sight? Xrn2 and transcriptional termination by RNA polymerase II
por: Eaton, Joshua D., et al.
Publicado: (2018)

A link between nuclear RNA surveillance, the human exosome and RNA polymerase II transcriptional termination
por: de Almeida, Sérgio F., et al.
Publicado: (2010)

MiR-21 is an Ngf-Modulated MicroRNA That Supports Ngf Signaling and Regulates Neuronal Degeneration in PC12 Cells
por: Montalban, Enrica, et al.
Publicado: (2014)

Cloning of the sea urchin mitochondrial RNA polymerase and reconstitution of the transcription termination system
por: Polosa, Paola Loguercio, et al.
Publicado: (2007)

Widespread occurrence of non-canonical transcription termination by human RNA polymerase III
por: Orioli, Andrea, et al.
Publicado: (2011)

Transcription activation depends on the length of the RNA polymerase II C‐terminal domain
por: Sawicka, Anna, et al.
Publicado: (2021)

RNA polymerase II CTD is dispensable for transcription and required for termination in human cells
por: Yahia, Yousra, et al.
Publicado: (2023)

Transcription by RNA polymerase III: insights into mechanism and regulation
por: Turowski, Tomasz W., et al.
Publicado: (2016)

SINE transcription by RNA polymerase III is suppressed by histone methylation but not by DNA methylation
por: Varshney, Dhaval, et al.
Publicado: (2015)

Compensatory RNA polymerase 2 loading determines the efficacy and transcriptional selectivity of JQ1 in Myc-driven tumors
por: Donato, E, et al.
Publicado: (2017)

Role of the RNA/DNA kinase Grc3 in transcription termination by RNA polymerase I
por: Braglia, Priscilla, et al.
Publicado: (2010)

Rho-dependent transcription termination in bacteria recycles RNA polymerases stalled at DNA lesions
por: Jain, Sriyans, et al.
Publicado: (2019)

Transcription reinitiation by recycling RNA polymerase that diffuses on DNA after releasing terminated RNA
por: Kang, Wooyoung, et al.
Publicado: (2020)

RNA Polymerase II CTD phosphatase Rtr1 fine-tunes transcription termination
por: Victorino, Jose F., et al.
Publicado: (2020)

Identification and Functional Characterization of Novel MYC-Regulated Long Noncoding RNAs in Group 3 Medulloblastoma
por: Rea, Jessica, et al.
Publicado: (2021)

Structural insights into transcription initiation by yeast RNA polymerase I
por: Sadian, Yashar, et al.
Publicado: (2017)

Dissecting transcriptional amplification by MYC
por: Nie, Zuqin, et al.
Publicado: (2020)

AT-rich sequence elements promote nascent transcript cleavage leading to RNA polymerase II termination
por: White, Eleanor, et al.
Publicado: (2013)

The amino terminal extension of mammalian mitochondrial RNA polymerase ensures promoter specific transcription initiation
por: Posse, Viktor, et al.
Publicado: (2014)

In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release
por: Ding, Ke, et al.
Publicado: (2019)

Site-specific methylation and acetylation of lysine residues in the C-terminal domain (CTD) of RNA polymerase II
por: Voss, Kirsten, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_unsvfj60eig6u7uidkkjlui34u