The Role of the Hydrogen Bond Network in Maintaining Heme Pocket Stability and Protein Function Specificity of C. diphtheriae Coproheme Decarboxylase

Monoderm bacteria accumulate heme b via the coproporphyrin-dependent biosynthesis pathway. In the final step, in the presence of two molecules of H(2)O(2), the propionate groups of coproheme at positions 2 and 4 are decarboxylated to form vinyl groups by coproheme decarboxylase (ChdC), in a stepwise...

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Detalles Bibliográficos
Autores principales: Sebastiani, Federico, Baroni, Chiara, Patil, Gaurav, Dali, Andrea, Becucci, Maurizio, Hofbauer, Stefan, Smulevich, Giulietta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953210/
https://www.ncbi.nlm.nih.gov/pubmed/36830604
http://dx.doi.org/10.3390/biom13020235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953210/
https://www.ncbi.nlm.nih.gov/pubmed/36830604
http://dx.doi.org/10.3390/biom13020235

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