Cargando…

The Anti-Epileptic Drugs Lamotrigine and Valproic Acid Reduce the Cardiac Sodium Current

Anti-epileptic drugs (AEDs) are associated with increased risk of sudden cardiac death. To establish whether gabapentin, lamotrigine, levetiracetam, pregabalin, and valproic acid reduce the Na(v)1.5 current, we conducted whole-cell patch-clamp studies to study the effects of the five AEDs on current...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jia, Lixia, Verkerk, Arie O., Tan, Hanno L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953282/ https://www.ncbi.nlm.nih.gov/pubmed/36831014 http://dx.doi.org/10.3390/biomedicines11020477

Ejemplares similares

Carbamazepine Increases the Risk of Sudden Cardiac Arrest by a Reduction of the Cardiac Sodium Current
por: Jia, Lixia, et al.
Publicado: (2022)

Symptomatic hypocalcemia in an epileptic child treated with valproic acid plus lamotrigine: a case report
por: Praticò, Andrea Domenico, et al.
Publicado: (2009)

The Antidepressant Paroxetine Reduces the Cardiac Sodium Current
por: Plijter, Ingmar S., et al.
Publicado: (2023)

The opioid tramadol blocks the cardiac sodium channel Na(v)1.5 in HEK293 cells
por: Jia, Lixia, et al.
Publicado: (2023)

Lamotrigine-Valproic Acid Interaction Leading to Stevens–Johnson Syndrome
por: Vázquez, Marta, et al.
Publicado: (2018)

Toxic Epidermal Necrolysis Due to Concomitant Use of Lamotrigine and Valproic Acid
por: Kaur, Sukhjot, et al.
Publicado: (2013)

Stevens–Johnson syndrome induced by a combination of lamotrigine and valproic acid
por: Kavitha, S., et al.
Publicado: (2015)

Anti-Epileptic Drug Combination Efficacy in an In Vitro Seizure Model – Phenytoin and Valproate, Lamotrigine and Valproate
por: Taing, Kim Det, et al.
Publicado: (2017)

A Case of Toxic Epidermal Necrolysis Caused by Lamotrigine Combined With Valproic Acid and Literature Review
por: Liu, Haifeng, et al.
Publicado: (2023)

Is sodium current present in human sinoatrial node cells?
por: Verkerk, Arie O., et al.
Publicado: (2009)

Assessment of atherosclerotic risk among patients with epilepsy on valproic acid, lamotrigine, and carbamazepine treatment
por: Zuberi, Nudrat A., et al.
Publicado: (2017)

The Anti-Epileptic Drug Valproic Acid (VPA) Inhibits Steroidogenesis in Bovine Theca and Granulosa Cells In Vitro
por: Glister, Claire, et al.
Publicado: (2012)

Cardiac sodium channel inhibition by lamotrigine: In vitro characterization and clinical implications
por: Ingleby‐Talecki, Lindsey, et al.
Publicado: (2022)

Steven-Johnson Syndrome Induced by Lamotrigine and Valproic Acid in a Pediatric Patient: A Case Report
por: Espinosa-Aguilar, Eunice-Jazmín, et al.
Publicado: (2023)

Efficacy, safety, and potential of extended-release lamotrigine in the treatment of epileptic patients
por: Błaszczyk, Barbara, et al.
Publicado: (2010)

Alterations in the carnitine metabolism in epileptic children treated with valproic acid.
por: Chung, S., et al.
Publicado: (1997)

Case report: Progressive skin rash and lymphadenopathy associated with lamotrigine−valproic acid combination in a bipolar adolescent
por: Duan, Yingxu, et al.
Publicado: (2023)

Effect of hydroalcoholic extract of ginger on the liver of epileptic female rats treated with lamotrigine
por: Poorrostami, Ameneh, et al.
Publicado: (2014)

Lipidomic characteristics and clinical findings of epileptic patients treated with valproic acid
por: Li, Rong, et al.
Publicado: (2019)

The potential antiepileptic activity of astaxanthin in epileptic rats treated with valproic acid
por: Ata Yaseen Abdulqader, Yussra, et al.
Publicado: (2021)

Epilepsy-Induced High Affinity Blockade of the Cardiac Sodium Current I(Na) by Lamotrigine; A Potential for Acquired Arrythmias
por: Contreras Vite, Juan Antonio, et al.
Publicado: (2022)

Comparison of Valproic acid Clearance between Epileptic Patients and Patients with Acute Mania
por: Mohammadpour, Amir Hooshang, et al.
Publicado: (2011)

Genetic Variations of ABCC2 Gene Associated with Adverse Drug Reactions to Valproic Acid in Korean Epileptic Patients
por: Yi, Ji Hyun, et al.
Publicado: (2013)

Differential Gene Expression Profile Induced by Valproic Acid (VPA) in Pediatric Epileptic Patients
por: Floriano-Sánchez, Esaú, et al.
Publicado: (2018)

Vitamin D Status in Epileptic Children on Valproic Acid; a Case-Control Study
por: Abdullah, Ameena Taha, et al.
Publicado: (2020)

Lamotrigine Drug Interactions: Ignorance is not Bliss
por: Armstrong, Austin G., et al.
Publicado: (2022)

Cardiac morbidity and mortality associated with the use of lamotrigine
por: Christensen, Jakob, et al.
Publicado: (2022)

Apparent clearance of valproic acid in elderly epileptic patients: estimation of the confounding effect of albumin concentration
por: Lampon, Natalia, et al.
Publicado: (2012)

Efficacy and safety of sodium valproate plus lamotrigine in children with refractory epilepsy
por: Zhang, Dongli, et al.
Publicado: (2020)

Pharmacokinetic changes and therapeutic drug monitoring of lamotrigine during pregnancy
por: Ding, Ye, et al.
Publicado: (2019)

The serum acylcarnitines profile in epileptic children treated with valproic acid and the protective roles of peroxisome proliferator-activated receptor a activation in valproic acid-induced liver injury
por: Ma, Yiyi, et al.
Publicado: (2022)

Effect of antiepileptic drug comedication on lamotrigine concentrations
por: Lovrić, Mila, et al.
Publicado: (2018)

Pharmacotherapeutics of epilepsy: use of lamotrigine and expectations for lamotrigine extended release
por: Werz, Mary Ann
Publicado: (2008)

Repurposing the anti-epileptic drug sodium valproate as an adjuvant treatment for diffuse intrinsic pontine glioma
por: Killick-Cole, Clare L., et al.
Publicado: (2017)

Cardiac sodium channelopathies
por: Amin, Ahmad S., et al.
Publicado: (2009)

Calcium Transient and Sodium-Calcium Exchange Current in Human versus Rabbit Sinoatrial Node Pacemaker Cells
por: Verkerk, Arie O., et al.
Publicado: (2013)

Anti-Epileptic Drug Toxicity in Children
por: Choonara, Imti
Publicado: (2018)

Sulfonylurea antidiabetics are associated with lower risk of out‐of‐hospital cardiac arrest: Real‐world data from a population‐based study
por: Eroglu, Talip E., et al.
Publicado: (2021)

The effect of lamotrigine on epilepsy
por: Ebrahimi, Hossein Ali, et al.
Publicado: (2012)

Lamotrigine ethanol monosolvate
por: Hall, Charlie L., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_t0uq4o0t34s7d4vloq5dpmh85d