Commonly Used Therapeutics Associated with Changes in Arousal Inhibit GABA(A)R Activation

GABA(A) receptor-positive modulators are well-known to induce sedation, sleep, and general anesthesia. Conversely, GABA(A) receptor negative allosteric modulators (GABA(A)RNAMs) can increase arousal and induce seizures. Motivated by our studies with patients with hypersomnia, and our discovery that...

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Detalles Bibliográficos
Autores principales: Kaplan, Anling, Nash, Abigail I., Freeman, Amanda A. H., Lewicki, Lauren G., Rye, David B., Trotti, Lynn Marie, Brandt, Asher L., Jenkins, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953295/
https://www.ncbi.nlm.nih.gov/pubmed/36830736
http://dx.doi.org/10.3390/biom13020365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953295/
https://www.ncbi.nlm.nih.gov/pubmed/36830736
http://dx.doi.org/10.3390/biom13020365

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