The Mechanism of Enantioselective Neurosteroid Actions on GABA(A) Receptors

The neurosteroid allopregnanolone (ALLO) and pregnanolone (PREG), are equally effective positive allosteric modulators (PAMs) of GABA(A) receptors. Interestingly, the PAM effects of ALLO are strongly enantioselective, whereas those of PREG are not. This study was aimed at determining the basis for t...

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Detalles Bibliográficos
Autores principales: Tateiwa, Hiroki, Chintala, Satyanarayana M., Chen, Ziwei, Wang, Lei, Amtashar, Fatima, Bracamontes, John, Germann, Allison L., Pierce, Spencer R., Covey, Douglas F., Akk, Gustav, Evers, Alex S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953308/
https://www.ncbi.nlm.nih.gov/pubmed/36830708
http://dx.doi.org/10.3390/biom13020341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953308/
https://www.ncbi.nlm.nih.gov/pubmed/36830708
http://dx.doi.org/10.3390/biom13020341

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