Peptides That Block RAS-p21 Protein-Induced Cell Transformation

This is a review of approaches to the design of peptides and small molecules that selectively block the oncogenic RAS-p21 protein in ras-induced cancers. Single amino acid substitutions in this protein, at critical positions such as at Gly 12 and Gln 61, cause the protein to become oncogenic. These...

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Detalles Bibliográficos
Autores principales: Pincus, Matthew R., Lin, Bo, Patel, Purvi, Gabutan, Elmer, Zohar, Nitzan, Bowne, Wilbur B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953342/
https://www.ncbi.nlm.nih.gov/pubmed/36831007
http://dx.doi.org/10.3390/biomedicines11020471

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953342/
https://www.ncbi.nlm.nih.gov/pubmed/36831007
http://dx.doi.org/10.3390/biomedicines11020471

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