LRRK2 Kinase Inhibition Attenuates Astrocytic Activation in Response to Amyloid β(1-42) Fibrils

Intracerebral accumulation of amyloid-β in the extracellular plaques of Alzheimer’s disease (AD) brains represents the main cause of reactive astrogliosis and neuroinflammatory response. Of relevance, leucine-rich repeat kinase 2 (LRRK2), a kinase linked to genetic and sporadic Parkinson’s disease (...

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Detalles Bibliográficos
Autores principales: Filippini, Alice, Salvi, Valentina, Dattilo, Vincenzo, Magri, Chiara, Castrezzati, Stefania, Veerhuis, Robert, Bosisio, Daniela, Gennarelli, Massimo, Russo, Isabella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953366/
https://www.ncbi.nlm.nih.gov/pubmed/36830676
http://dx.doi.org/10.3390/biom13020307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953366/
https://www.ncbi.nlm.nih.gov/pubmed/36830676
http://dx.doi.org/10.3390/biom13020307

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