Screening MT1-MMP Activity and Inhibition in Three-Dimensional Tumor Spheroids

Membrane type 1 matrix metalloproteinase (MT1-MMP) has been shown to be crucial for tumor angiogenesis, invasion, and metastasis, and thus MT1-MMP is a high priority target for potential cancer therapies. To properly evaluate MT1-MMP inhibitors, a screening protocol is desired by which enzyme activi...

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Detalles Bibliográficos
Autores principales: Knapinska, Anna M., Drotleff, Gary, Chai, Cedric, Twohill, Destiny, Ernce, Alexa, Tokmina-Roszyk, Dorota, Grande, Isabella, Rodriguez, Michelle, Larson, Brad, Fields, Gregg B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953393/
https://www.ncbi.nlm.nih.gov/pubmed/36831098
http://dx.doi.org/10.3390/biomedicines11020562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953393/
https://www.ncbi.nlm.nih.gov/pubmed/36831098
http://dx.doi.org/10.3390/biomedicines11020562

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