The Effect of Tortuosity on Permeability of Porous Scaffold

In designing porous scaffolds, permeability is essential to consider as a function of cell migration and bone tissue regeneration. Good permeability has been achieved by mimicking the complexity of natural cancellous bone. In this study, a porous scaffold was developed according to the morphological...

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Autores principales: Prakoso, Akbar Teguh, Basri, Hasan, Adanta, Dendy, Yani, Irsyadi, Ammarullah, Muhammad Imam, Akbar, Imam, Ghazali, Farah Amira, Syahrom, Ardiyansyah, Kamarul, Tunku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953537/
https://www.ncbi.nlm.nih.gov/pubmed/36830961
http://dx.doi.org/10.3390/biomedicines11020427
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author Prakoso, Akbar Teguh
Basri, Hasan
Adanta, Dendy
Yani, Irsyadi
Ammarullah, Muhammad Imam
Akbar, Imam
Ghazali, Farah Amira
Syahrom, Ardiyansyah
Kamarul, Tunku
author_facet Prakoso, Akbar Teguh
Basri, Hasan
Adanta, Dendy
Yani, Irsyadi
Ammarullah, Muhammad Imam
Akbar, Imam
Ghazali, Farah Amira
Syahrom, Ardiyansyah
Kamarul, Tunku
author_sort Prakoso, Akbar Teguh
collection PubMed
description In designing porous scaffolds, permeability is essential to consider as a function of cell migration and bone tissue regeneration. Good permeability has been achieved by mimicking the complexity of natural cancellous bone. In this study, a porous scaffold was developed according to the morphological indices of cancellous bone (porosity, specific surface area, thickness, and tortuosity). The computational fluid dynamics method analyzes the fluid flow through the scaffold. The permeability values of natural cancellous bone and three types of scaffolds (cubic, octahedron pillar, and Schoen’s gyroid) were compared. The results showed that the permeability of the Negative Schwarz Primitive (NSP) scaffold model was similar to that of natural cancellous bone, which was in the range of 2.0 × 10(−11) m(2) to 4.0 × 10(−10) m(2). In addition, it was observed that the tortuosity parameter significantly affected the scaffold’s permeability and shear stress values. The tortuosity value of the NSP scaffold was in the range of 1.5–2.8. Therefore, tortuosity can be manipulated by changing the curvature of the surface scaffold radius to obtain a superior bone tissue engineering construction supporting cell migration and tissue regeneration. This parameter should be considered when making new scaffolds, such as our NSP. Such efforts will produce a scaffold architecturally and functionally close to the natural cancellous bone, as demonstrated in this study.
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spelling pubmed-99535372023-02-25 The Effect of Tortuosity on Permeability of Porous Scaffold Prakoso, Akbar Teguh Basri, Hasan Adanta, Dendy Yani, Irsyadi Ammarullah, Muhammad Imam Akbar, Imam Ghazali, Farah Amira Syahrom, Ardiyansyah Kamarul, Tunku Biomedicines Article In designing porous scaffolds, permeability is essential to consider as a function of cell migration and bone tissue regeneration. Good permeability has been achieved by mimicking the complexity of natural cancellous bone. In this study, a porous scaffold was developed according to the morphological indices of cancellous bone (porosity, specific surface area, thickness, and tortuosity). The computational fluid dynamics method analyzes the fluid flow through the scaffold. The permeability values of natural cancellous bone and three types of scaffolds (cubic, octahedron pillar, and Schoen’s gyroid) were compared. The results showed that the permeability of the Negative Schwarz Primitive (NSP) scaffold model was similar to that of natural cancellous bone, which was in the range of 2.0 × 10(−11) m(2) to 4.0 × 10(−10) m(2). In addition, it was observed that the tortuosity parameter significantly affected the scaffold’s permeability and shear stress values. The tortuosity value of the NSP scaffold was in the range of 1.5–2.8. Therefore, tortuosity can be manipulated by changing the curvature of the surface scaffold radius to obtain a superior bone tissue engineering construction supporting cell migration and tissue regeneration. This parameter should be considered when making new scaffolds, such as our NSP. Such efforts will produce a scaffold architecturally and functionally close to the natural cancellous bone, as demonstrated in this study. MDPI 2023-02-01 /pmc/articles/PMC9953537/ /pubmed/36830961 http://dx.doi.org/10.3390/biomedicines11020427 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Prakoso, Akbar Teguh
Basri, Hasan
Adanta, Dendy
Yani, Irsyadi
Ammarullah, Muhammad Imam
Akbar, Imam
Ghazali, Farah Amira
Syahrom, Ardiyansyah
Kamarul, Tunku
The Effect of Tortuosity on Permeability of Porous Scaffold
title The Effect of Tortuosity on Permeability of Porous Scaffold
title_full The Effect of Tortuosity on Permeability of Porous Scaffold
title_fullStr The Effect of Tortuosity on Permeability of Porous Scaffold
title_full_unstemmed The Effect of Tortuosity on Permeability of Porous Scaffold
title_short The Effect of Tortuosity on Permeability of Porous Scaffold
title_sort effect of tortuosity on permeability of porous scaffold
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953537/
https://www.ncbi.nlm.nih.gov/pubmed/36830961
http://dx.doi.org/10.3390/biomedicines11020427
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