A Proteome-Wide Effect of PHF8 Knockdown on Cortical Neurons Shows Downregulation of Parkinson’s Disease-Associated Protein Alpha-Synuclein and Its Interactors

Synaptic dysfunction may underlie the pathophysiology of Parkinson’s disease (PD), a presently incurable condition characterized by motor and cognitive symptoms. Here, we used quantitative proteomics to study the role of PHD Finger Protein 8 (PHF8), a histone demethylating enzyme found to be mutated...

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Detalles Bibliográficos
Autores principales: Oey, Nicodemus E., Zhou, Lei, Chan, Christine Hui Shan, VanDongen, Antonius M. J., Tan, Eng King
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953648/
https://www.ncbi.nlm.nih.gov/pubmed/36831023
http://dx.doi.org/10.3390/biomedicines11020486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953648/
https://www.ncbi.nlm.nih.gov/pubmed/36831023
http://dx.doi.org/10.3390/biomedicines11020486

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