Using ΔK280 Tau(RD) Folding Reporter Cells to Screen TRKB Agonists as Alzheimer’s Disease Treatment Strategy

Misfolded aggregation of the hyperphosphorylated microtubule binding protein Tau in the brain is a pathological hallmark of Alzheimer’s disease (AD). Tau aggregation downregulates brain-derived neurotrophic factor (BDNF)/tropomycin receptor kinase B (TRKB) signaling and leads to neurotoxicity. There...

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Detalles Bibliográficos
Autores principales: Weng, Zheng-Kui, Lin, Te-Hsien, Chang, Kuo-Hsuan, Chiu, Ya-Jen, Lin, Chih-Hsin, Tseng, Pei-Hsuan, Sun, Ying-Chieh, Lin, Wenwei, Lee-Chen, Guey-Jen, Chen, Chiung-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953660/
https://www.ncbi.nlm.nih.gov/pubmed/36830589
http://dx.doi.org/10.3390/biom13020219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953660/
https://www.ncbi.nlm.nih.gov/pubmed/36830589
http://dx.doi.org/10.3390/biom13020219

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