Targeting Mitochondrial IDH2 Enhances Antitumor Activity of Cisplatin in Lung Cancer via ROS-Mediated Mechanism

Mitochondrial isocitrate dehydrogenase 2 (IDH2) is an important metabolic enzyme in the tricarboxylic acid cycle (TCA) cycle. Our previous study showed that high expression of wild-type IDH2 promotes the proliferation of lung cancer cells. This study aims to test the potential of targeting IDH2 as a...

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Detalles Bibliográficos
Autores principales: Li, He, Li, Jiang-jiang, Lu, Wenhua, Yang, Jing, Xia, Yunfei, Huang, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953680/
https://www.ncbi.nlm.nih.gov/pubmed/36831011
http://dx.doi.org/10.3390/biomedicines11020475

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953680/
https://www.ncbi.nlm.nih.gov/pubmed/36831011
http://dx.doi.org/10.3390/biomedicines11020475

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