Transforming Cross-Linked Cyclic Dimers of KR-12 into Stable and Potent Antimicrobial Drug Leads

Is it possible to enhance structural stability and biological activity of KR-12, a truncated antimicrobial peptide derived from the human host defense peptide LL-37? Based on the mapping of essential residues in KR-12, we have designed backbone-cyclized dimers, cross-linked via a disulfide bond to i...

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Detalles Bibliográficos
Autores principales: Muhammad, Taj, Strömstedt, Adam A., Gunasekera, Sunithi, Göransson, Ulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953701/
https://www.ncbi.nlm.nih.gov/pubmed/36831040
http://dx.doi.org/10.3390/biomedicines11020504

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953701/
https://www.ncbi.nlm.nih.gov/pubmed/36831040
http://dx.doi.org/10.3390/biomedicines11020504

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