Adipose Tissue and Adipose-Tissue-Derived Cell Therapies for the Treatment of the Face and Hands of Patients Suffering from Systemic Sclerosis

Adipose tissue is recognized as a valuable source of cells with angiogenic, immunomodulatory, reparative and antifibrotic properties and emerged as a therapeutic alternative for the regeneration and repair of damaged tissues. The use of adipose-tissue-based therapy is expanding in autoimmune disease...

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Autores principales: Coulange Zavarro, Anouck, Velier, Mélanie, Arcani, Robin, Abellan Lopez, Maxime, Simoncini, Stéphanie, Benyamine, Audrey, Gomes De Pinho, Quentin, Coatmeur, Raphael, Wang, Jiucun, Xia, Jingjing, Barone, Ludovica, Casanova, Dominique, Dignat-George, Françoise, Sabatier, Florence, Granel, Brigitte, Magalon, Jérémy, Daumas, Aurélie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953720/
https://www.ncbi.nlm.nih.gov/pubmed/36830886
http://dx.doi.org/10.3390/biomedicines11020348
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author Coulange Zavarro, Anouck
Velier, Mélanie
Arcani, Robin
Abellan Lopez, Maxime
Simoncini, Stéphanie
Benyamine, Audrey
Gomes De Pinho, Quentin
Coatmeur, Raphael
Wang, Jiucun
Xia, Jingjing
Barone, Ludovica
Casanova, Dominique
Dignat-George, Françoise
Sabatier, Florence
Granel, Brigitte
Magalon, Jérémy
Daumas, Aurélie
author_facet Coulange Zavarro, Anouck
Velier, Mélanie
Arcani, Robin
Abellan Lopez, Maxime
Simoncini, Stéphanie
Benyamine, Audrey
Gomes De Pinho, Quentin
Coatmeur, Raphael
Wang, Jiucun
Xia, Jingjing
Barone, Ludovica
Casanova, Dominique
Dignat-George, Françoise
Sabatier, Florence
Granel, Brigitte
Magalon, Jérémy
Daumas, Aurélie
author_sort Coulange Zavarro, Anouck
collection PubMed
description Adipose tissue is recognized as a valuable source of cells with angiogenic, immunomodulatory, reparative and antifibrotic properties and emerged as a therapeutic alternative for the regeneration and repair of damaged tissues. The use of adipose-tissue-based therapy is expanding in autoimmune diseases, particularly in Systemic Sclerosis (SSc), a disease in which hands and face are severely affected, leading to disability and a decrease in quality of life. Combining the advantage of an abundant supply of fat tissue and a high abundance of stem/stromal cells, fat grafting and adipose tissue-derived cell-based therapies are attractive therapeutic options in SSc. This review aims to synthesize the evidence to determine the effects of the use of these biological products for face and hands treatment in the context of SSc. This highlights several points: the need to use relevant effectiveness criteria taking into account the clinical heterogeneity of SSc in order to facilitate assessment and comparison of innovative therapies; second, it reveals some impacts of the disease on fat-grafting success; third, an important heterogeneity was noticed regarding the manufacturing of the adipose-derived products and lastly, it shows a lack of robust evidence from controlled trials comparing adipose-derived products with standard care.
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spelling pubmed-99537202023-02-25 Adipose Tissue and Adipose-Tissue-Derived Cell Therapies for the Treatment of the Face and Hands of Patients Suffering from Systemic Sclerosis Coulange Zavarro, Anouck Velier, Mélanie Arcani, Robin Abellan Lopez, Maxime Simoncini, Stéphanie Benyamine, Audrey Gomes De Pinho, Quentin Coatmeur, Raphael Wang, Jiucun Xia, Jingjing Barone, Ludovica Casanova, Dominique Dignat-George, Françoise Sabatier, Florence Granel, Brigitte Magalon, Jérémy Daumas, Aurélie Biomedicines Review Adipose tissue is recognized as a valuable source of cells with angiogenic, immunomodulatory, reparative and antifibrotic properties and emerged as a therapeutic alternative for the regeneration and repair of damaged tissues. The use of adipose-tissue-based therapy is expanding in autoimmune diseases, particularly in Systemic Sclerosis (SSc), a disease in which hands and face are severely affected, leading to disability and a decrease in quality of life. Combining the advantage of an abundant supply of fat tissue and a high abundance of stem/stromal cells, fat grafting and adipose tissue-derived cell-based therapies are attractive therapeutic options in SSc. This review aims to synthesize the evidence to determine the effects of the use of these biological products for face and hands treatment in the context of SSc. This highlights several points: the need to use relevant effectiveness criteria taking into account the clinical heterogeneity of SSc in order to facilitate assessment and comparison of innovative therapies; second, it reveals some impacts of the disease on fat-grafting success; third, an important heterogeneity was noticed regarding the manufacturing of the adipose-derived products and lastly, it shows a lack of robust evidence from controlled trials comparing adipose-derived products with standard care. MDPI 2023-01-26 /pmc/articles/PMC9953720/ /pubmed/36830886 http://dx.doi.org/10.3390/biomedicines11020348 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Coulange Zavarro, Anouck
Velier, Mélanie
Arcani, Robin
Abellan Lopez, Maxime
Simoncini, Stéphanie
Benyamine, Audrey
Gomes De Pinho, Quentin
Coatmeur, Raphael
Wang, Jiucun
Xia, Jingjing
Barone, Ludovica
Casanova, Dominique
Dignat-George, Françoise
Sabatier, Florence
Granel, Brigitte
Magalon, Jérémy
Daumas, Aurélie
Adipose Tissue and Adipose-Tissue-Derived Cell Therapies for the Treatment of the Face and Hands of Patients Suffering from Systemic Sclerosis
title Adipose Tissue and Adipose-Tissue-Derived Cell Therapies for the Treatment of the Face and Hands of Patients Suffering from Systemic Sclerosis
title_full Adipose Tissue and Adipose-Tissue-Derived Cell Therapies for the Treatment of the Face and Hands of Patients Suffering from Systemic Sclerosis
title_fullStr Adipose Tissue and Adipose-Tissue-Derived Cell Therapies for the Treatment of the Face and Hands of Patients Suffering from Systemic Sclerosis
title_full_unstemmed Adipose Tissue and Adipose-Tissue-Derived Cell Therapies for the Treatment of the Face and Hands of Patients Suffering from Systemic Sclerosis
title_short Adipose Tissue and Adipose-Tissue-Derived Cell Therapies for the Treatment of the Face and Hands of Patients Suffering from Systemic Sclerosis
title_sort adipose tissue and adipose-tissue-derived cell therapies for the treatment of the face and hands of patients suffering from systemic sclerosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953720/
https://www.ncbi.nlm.nih.gov/pubmed/36830886
http://dx.doi.org/10.3390/biomedicines11020348
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