Targeted Degradation of Androgen Receptor by VNPP433-3β in Castration-Resistant Prostate Cancer Cells Implicates Interaction with E3 Ligase MDM2 Resulting in Ubiquitin-Proteasomal Degradation

SIMPLE SUMMARY: In this study, we demonstrate the potential role of VNPP433-3β as molecular glue that induces physical proximity between the Androgen Receptor and MDM2 E3 ligase in prostate cancer cells. The interaction promotes MDM2-mediated ubiquitination of AR and its subsequent proteasomal degra...

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Detalles Bibliográficos
Autores principales: Thomas, Elizabeth, Thankan, Retheesh S., Purushottamachar, Puranik, Weber, David J., Njar, Vincent C. O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954018/
https://www.ncbi.nlm.nih.gov/pubmed/36831540
http://dx.doi.org/10.3390/cancers15041198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954018/
https://www.ncbi.nlm.nih.gov/pubmed/36831540
http://dx.doi.org/10.3390/cancers15041198

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