Integrin αvβ3 Is a Master Regulator of Resistance to TKI-Induced Ferroptosis in HER2-Positive Breast Cancer

SIMPLE SUMMARY: Intrinsic or acquired resistance to clinically approved targeted therapies for breast cancer patients is a major cause of treatment failure. Our findings provide conclusive functional evidence that the cell adhesion receptor αvβ3 integrin is a critical mediator of resistance to Human...

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Detalles Bibliográficos
Autores principales: Nagpal, Aadya, Needham, Kristen, Lane, Darius J. R., Ayton, Scott, Redvers, Richard P., John, Melissa, Selistre-de-Araujo, Heloisa S., Denoyer, Delphine, Pouliot, Normand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954089/
https://www.ncbi.nlm.nih.gov/pubmed/36831558
http://dx.doi.org/10.3390/cancers15041216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954089/
https://www.ncbi.nlm.nih.gov/pubmed/36831558
http://dx.doi.org/10.3390/cancers15041216

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