SMAC Mimetics Synergistically Cooperate with HDAC Inhibitors Enhancing TNF-α Autocrine Signaling

SIMPLE SUMMARY: The combination of a SMAC mimetic with an HDAC inhibitor is a novel and promising strategy for cancer treatment. The HDAC inhibitor mechanistically synergizes with SMAC mimetics by stimulating autocrine TNF-α production. ABSTRACT: The overexpression of inhibitor of apoptosis (IAP) pr...

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Detalles Bibliográficos
Autores principales: Shibuya, Yusuke, Kudo, Kei, Zeligs, Kristen P., Anderson, David, Hernandez, Lidia, Ning, Franklin, Cole, Christopher B., Fergusson, Maria, Kedei, Noemi, Lyons, John, Taylor, Jason, Korrapati, Soumya, Annunziata, Christina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954505/
https://www.ncbi.nlm.nih.gov/pubmed/36831656
http://dx.doi.org/10.3390/cancers15041315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954505/
https://www.ncbi.nlm.nih.gov/pubmed/36831656
http://dx.doi.org/10.3390/cancers15041315

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