miR-34a and IRE1A/XBP-1(S) Form a Double-Negative Feedback Loop to Regulate Hypoxia-Induced EMT, Metastasis, Chemo-Resistance and Autophagy

SIMPLE SUMMARY: The hypoxic tumor microenvironment is a key factor in the formation of metastasis and treatment resistance. We recently identified a new regulatory network consisting of the hypoxia-inducible transcription factor HIF-1A and the p53-inducible miR-34a that determines whether a tumor ce...

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Detalles Bibliográficos
Autores principales: Bouznad, Nassim, Rokavec, Matjaz, Öner, Meryem Gülfem, Hermeking, Heiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954576/
https://www.ncbi.nlm.nih.gov/pubmed/36831485
http://dx.doi.org/10.3390/cancers15041143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954576/
https://www.ncbi.nlm.nih.gov/pubmed/36831485
http://dx.doi.org/10.3390/cancers15041143

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