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Deciphering the QR Code of the CRISPR-Cas9 System: Synergy between Gln768 (Q) and Arg976 (R)
[Image: see text] Markov state models (MSMs) and machine learning (ML) algorithms can extrapolate the long-time-scale behavior of large biomolecules from molecular dynamics (MD) trajectories. In this study, an MD–MSM–ML scheme has been applied to probe the large endonuclease (Cas9) in the bacterial...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955204/ https://www.ncbi.nlm.nih.gov/pubmed/36855610 http://dx.doi.org/10.1021/acsphyschemau.2c00041 |