Lymphatic-draining nanoparticles deliver Bay K8644 payload to lymphatic vessels and enhance their pumping function

Dysfunction of collecting lymphatic vessel pumping is associated with an array of pathologies. S-(−)-Bay K8644 (BayK), a small-molecule agonist of L-type calcium channels, improves vessel contractility ex vivo but has been left unexplored in vivo because of poor lymphatic access and risk of deleteri...

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Detalles Bibliográficos
Autores principales: Sestito, Lauren F., To, Kim H. T., Cribb, Matthew T., Archer, Paul A., Thomas, Susan N., Dixon, J. Brandon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956116/
https://www.ncbi.nlm.nih.gov/pubmed/36827374
http://dx.doi.org/10.1126/sciadv.abq0435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956116/
https://www.ncbi.nlm.nih.gov/pubmed/36827374
http://dx.doi.org/10.1126/sciadv.abq0435

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