Telomere Fragility and MiDAS: Managing the Gaps at the End of the Road

Telomeres present inherent difficulties to the DNA replication machinery due to their repetitive sequence content, formation of non-B DNA secondary structures, and the presence of the nucleo-protein t-loop. Especially in cancer cells, telomeres are hot spots for replication stress, which can result...

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Detalles Bibliográficos
Autores principales: Barnes, Ryan P., Thosar, Sanjana A., Opresko, Patricia L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956152/
https://www.ncbi.nlm.nih.gov/pubmed/36833275
http://dx.doi.org/10.3390/genes14020348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956152/
https://www.ncbi.nlm.nih.gov/pubmed/36833275
http://dx.doi.org/10.3390/genes14020348

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