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Pharmacogenetic allele variant frequencies: An analysis of the VA’s Million Veteran Program (MVP) as a representation of the diversity in US population
We present allele frequencies of pharmacogenomics relevant variants across multiple ancestry in a sample representative of the US population. We analyzed 658,582 individuals with genotype data and extracted pharmacogenomics relevant single nucleotide variant (SNV) alleles, human leukocyte antigens (...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956596/ https://www.ncbi.nlm.nih.gov/pubmed/36827430 http://dx.doi.org/10.1371/journal.pone.0274339 |
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author | Markianos, Kyriacos Dong, Frederic Gorman, Bryan Shi, Yunling Dochtermann, Daniel Saxena, Uma Devineni, Poornima Moser, Jennifer Muralidhar, Sumitra Ramoni, Rachel Tsao, Philip Pyarajan, Saiju Przygodzki, Ronald |
author_facet | Markianos, Kyriacos Dong, Frederic Gorman, Bryan Shi, Yunling Dochtermann, Daniel Saxena, Uma Devineni, Poornima Moser, Jennifer Muralidhar, Sumitra Ramoni, Rachel Tsao, Philip Pyarajan, Saiju Przygodzki, Ronald |
author_sort | Markianos, Kyriacos |
collection | PubMed |
description | We present allele frequencies of pharmacogenomics relevant variants across multiple ancestry in a sample representative of the US population. We analyzed 658,582 individuals with genotype data and extracted pharmacogenomics relevant single nucleotide variant (SNV) alleles, human leukocyte antigens (HLA) 4-digit alleles and an important copy number variant (CNV), the full deletion/duplication of CYP2D6. We compiled distinct allele frequency tables for European, African American, Hispanic, and Asian ancestry individuals. In addition, we compiled allele frequencies based on local ancestry reconstruction in the African-American (2-way deconvolution) and Hispanic (3-way deconvolution) cohorts. |
format | Online Article Text |
id | pubmed-9956596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-99565962023-02-25 Pharmacogenetic allele variant frequencies: An analysis of the VA’s Million Veteran Program (MVP) as a representation of the diversity in US population Markianos, Kyriacos Dong, Frederic Gorman, Bryan Shi, Yunling Dochtermann, Daniel Saxena, Uma Devineni, Poornima Moser, Jennifer Muralidhar, Sumitra Ramoni, Rachel Tsao, Philip Pyarajan, Saiju Przygodzki, Ronald PLoS One Research Article We present allele frequencies of pharmacogenomics relevant variants across multiple ancestry in a sample representative of the US population. We analyzed 658,582 individuals with genotype data and extracted pharmacogenomics relevant single nucleotide variant (SNV) alleles, human leukocyte antigens (HLA) 4-digit alleles and an important copy number variant (CNV), the full deletion/duplication of CYP2D6. We compiled distinct allele frequency tables for European, African American, Hispanic, and Asian ancestry individuals. In addition, we compiled allele frequencies based on local ancestry reconstruction in the African-American (2-way deconvolution) and Hispanic (3-way deconvolution) cohorts. Public Library of Science 2023-02-24 /pmc/articles/PMC9956596/ /pubmed/36827430 http://dx.doi.org/10.1371/journal.pone.0274339 Text en https://creativecommons.org/publicdomain/zero/1.0/This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication. |
spellingShingle | Research Article Markianos, Kyriacos Dong, Frederic Gorman, Bryan Shi, Yunling Dochtermann, Daniel Saxena, Uma Devineni, Poornima Moser, Jennifer Muralidhar, Sumitra Ramoni, Rachel Tsao, Philip Pyarajan, Saiju Przygodzki, Ronald Pharmacogenetic allele variant frequencies: An analysis of the VA’s Million Veteran Program (MVP) as a representation of the diversity in US population |
title | Pharmacogenetic allele variant frequencies: An analysis of the VA’s Million Veteran Program (MVP) as a representation of the diversity in US population |
title_full | Pharmacogenetic allele variant frequencies: An analysis of the VA’s Million Veteran Program (MVP) as a representation of the diversity in US population |
title_fullStr | Pharmacogenetic allele variant frequencies: An analysis of the VA’s Million Veteran Program (MVP) as a representation of the diversity in US population |
title_full_unstemmed | Pharmacogenetic allele variant frequencies: An analysis of the VA’s Million Veteran Program (MVP) as a representation of the diversity in US population |
title_short | Pharmacogenetic allele variant frequencies: An analysis of the VA’s Million Veteran Program (MVP) as a representation of the diversity in US population |
title_sort | pharmacogenetic allele variant frequencies: an analysis of the va’s million veteran program (mvp) as a representation of the diversity in us population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956596/ https://www.ncbi.nlm.nih.gov/pubmed/36827430 http://dx.doi.org/10.1371/journal.pone.0274339 |
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