Cargando…

Structural similarities between the metacyclic and bloodstream form variant surface glycoproteins of the African trypanosome

During infection of mammalian hosts, African trypanosomes thwart immunity using antigenic variation of the dense Variant Surface Glycoprotein (VSG) coat, accessing a large repertoire of several thousand genes and pseudogenes, and switching to antigenically distinct copies. The parasite is transferre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chandra, Monica, Đaković, Sara, Foti, Konstantina, Zeelen, Johan P., van Straaten, Monique, Aresta-Branco, Francisco, Tihon, Eliane, Lübbehusen, Nicole, Ruppert, Thomas, Glover, Lucy, Papavasiliou, F. Nina, Stebbins, C. Erec
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9956791/ https://www.ncbi.nlm.nih.gov/pubmed/36780870 http://dx.doi.org/10.1371/journal.pntd.0011093

Ejemplares similares

A structural classification of the variant surface glycoproteins of the African trypanosome
por: Đaković, Sara, et al.
Publicado: (2023)

Structure of Trypanosome Coat Protein VSGsur and Function in Suramin Resistance
por: Zeelen, Johan, et al.
Publicado: (2021)

African trypanosomes evade immune clearance by O-glycosylation of the VSG surface coat
por: Pinger, Jason, et al.
Publicado: (2018)

A trypanosome-derived immunotherapeutics platform elicits potent high-affinity antibodies, negating the effects of the synthetic opioid fentanyl
por: Triller, Gianna, et al.
Publicado: (2023)

TbSAP is a novel chromatin protein repressing metacyclic variant surface glycoprotein expression sites in bloodstream form Trypanosoma brucei
por: Davies, Carys, et al.
Publicado: (2021)

Masters of Disguise: Antigenic Variation and the VSG Coat in Trypanosoma brucei
por: Mugnier, Monica R., et al.
Publicado: (2016)

SUMOylated SNF2PH promotes variant surface glycoprotein expression in bloodstream trypanosomes
por: Saura, Andreu, et al.
Publicado: (2019)

Variant surface glycoprotein density defines an immune evasion threshold for African trypanosomes undergoing antigenic variation
por: Pinger, Jason, et al.
Publicado: (2017)

Bromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African Trypanosome
por: Schulz, Danae, et al.
Publicado: (2015)

Genetic Structure and Expression of the Surface Glycoprotein GP82, the Main Adhesin of Trypanosoma cruzi Metacyclic Trypomastigotes
por: Correa, Paulo Roberto Ceridorio, et al.
Publicado: (2013)

African trypanosomes expressing multiple VSGs are rapidly eliminated by the host immune system
por: Aresta-Branco, Francisco, et al.
Publicado: (2019)

Transmission of Leishmania metacyclic promastigotes by phlebotomine sand flies
por: Bates, Paul A.
Publicado: (2007)

Trafficking and release of Leishmania metacyclic HASPB on macrophage invasion
por: MacLean, Lorna M, et al.
Publicado: (2012)

Differential expression analysis of transcriptome data of Trypanosoma brucei RBP6 induction in procyclics leading to infectious metacyclics and bloodstream forms in vitro
por: Shi, Huafang, et al.
Publicado: (2018)

Metabolic insights into phosphofructokinase inhibition in bloodstream-form trypanosomes
por: Nare, Zandile, et al.
Publicado: (2023)

Cooperation between Apoptotic and Viable Metacyclics Enhances the Pathogenesis of Leishmaniasis
por: Wanderley, João Luiz Mendes, et al.
Publicado: (2009)

High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African trypanosomes
por: Hutchinson, Sebastian, et al.
Publicado: (2016)

Trypanosome Motion Represents an Adaptation to the Crowded Environment of the Vertebrate Bloodstream
por: Heddergott, Niko, et al.
Publicado: (2012)

Stimulation of metacyclogenesis in Leishmania (Mundinia) orientalis for mass production of metacyclic promastigotes
por: Chanmol, Wetpisit, et al.
Publicado: (2022)

Mechanisms of Assembly and Cellular Interactions for the Bacterial Genotoxin CDT
por: Nesic, Dragana, et al.
Publicado: (2005)

Correction: Mechanisms of Assembly and Cellular Interactions for the Bacterial Genotoxin CDT
por: Nesic, Dragana, et al.
Publicado: (2008)

Structure of the catalytic domain of the Salmonella virulence factor SseI
por: Bhaskaran, Shyam S., et al.
Publicado: (2012)

Chaperone Requirements for Biosynthesis of the Trypanosome Variant Surface Glycoprotein
por: Field, Mark C., et al.
Publicado: (2010)

Diversity in new flagellum tip attachment in bloodstream form African trypanosomes
por: Smithson, Laura, et al.
Publicado: (2022)

Genetic exchange in Trypanosoma brucei: Evidence for mating prior to metacyclic stage development
por: Tait, Andy, et al.
Publicado: (2007)

Controlling transferrin receptor trafficking with GPI-valence in bloodstream stage African trypanosomes
por: Tiengwe, Calvin, et al.
Publicado: (2017)

Surface Molecules Released by Trypanosoma cruzi Metacyclic Forms Downregulate Host Cell Invasion
por: Clemente, Tatiana Mordente, et al.
Publicado: (2016)

Slight temperature changes cause rapid transcriptomic responses in Trypanosoma cruzi metacyclic trypomastigotes
por: Cruz-Saavedra, Lissa, et al.
Publicado: (2020)

In vitro differentiation of Trypanosoma cruzi epimastigotes into metacyclic trypomastigotes using a biphasic medium
por: Rodríguez Durán, Jessica, et al.
Publicado: (2021)

Posttranslational modification and intracellular transport of a trypanosome variant surface glycoprotein
Publicado: (1986)

The role of invariant surface glycoprotein 75 in xenobiotic acquisition by African trypanosomes
por: Makarov, Alexandr, et al.
Publicado: (2023)

A conserved domain in type III secretion links the cytoplasmic domain of InvA to elements of the basal body
por: Lilic, Mirjana, et al.
Publicado: (2010)

How Does the VSG Coat of Bloodstream Form African Trypanosomes Interact with External Proteins?
por: Schwede, Angela, et al.
Publicado: (2015)

Non-linear hierarchy of the quorum sensing signalling pathway in bloodstream form African trypanosomes
por: McDonald, Lindsay, et al.
Publicado: (2018)

Alkaloids Induce Programmed Cell Death in Bloodstream Forms of Trypanosomes (Trypanosoma b. brucei)
por: Rosenkranz, Vera, et al.
Publicado: (2008)

Emerging challenges in understanding trypanosome antigenic variation
por: McCulloch, Richard, et al.
Publicado: (2017)

Quantifying Leishmania Metacyclic Promastigotes from Individual Sandfly Bites Reveals the Efficiency of Vector Transmission
por: Giraud, Emilie, et al.
Publicado: (2019)

Identification of protein profile in metacyclic and amastigote-like stages of Leishmania tropica: a proteomic approach
por: Ashrafmansouri, Marzieh, et al.
Publicado: (2022)

In vitro culture of freshly isolated Trypanosoma brucei brucei bloodstream forms results in gene copy-number changes
por: Mulindwa, Julius, et al.
Publicado: (2021)

Trypanin, a Component of the Flagellar Dynein Regulatory Complex, Is Essential in Bloodstream Form African Trypanosomes
por: Ralston, Katherine S, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_om11fsea7tb0h25ef8fflmn9fu