Cargando…

Understanding Drug Resistance of Wild-Type and L38HL Insertion Mutant of HIV-1 C Protease to Saquinavir

Acquired immunodeficiency syndrome (AIDS) is one of the most challenging infectious diseases to treat on a global scale. Understanding the mechanisms underlying the development of drug resistance is necessary for novel therapeutics. HIV subtype C is known to harbor mutations at critical positions of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Venkatachalam, Sankaran, Murlidharan, Nisha, Krishnan, Sowmya R., Ramakrishnan, C., Setshedi, Mpho, Pandian, Ramesh, Barh, Debmalya, Tiwari, Sandeep, Azevedo, Vasco, Sayed, Yasien, Gromiha, M. Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9957153/ https://www.ncbi.nlm.nih.gov/pubmed/36833460 http://dx.doi.org/10.3390/genes14020533

Ejemplares similares

Multi-omics-based identification of SARS-CoV-2 infection biology and candidate drugs against COVID-19
por: Barh, Debmalya, et al.
Publicado: (2020)

Semi-quantification and Potency Verification of the HIV Protease Inhibitor Based on the Matrix-Capsid Protein Immobilized Nickel (II)/NTA-Tol/Graphene Oxide/SPCE Electrochemical Biosensor
por: Thongkum, Weeraya, et al.
Publicado: (2023)

Linking common non-coding RNAs of human lung cancer and M. tuberculosis
por: Barh, Debmalya, et al.
Publicado: (2018)

Current Trends in Experimental and Computational Approaches to Combat Antimicrobial Resistance
por: Imchen, Madangchanok, et al.
Publicado: (2020)

A novel strategy of epitope design in Neisseria gonorrhoeae
por: Barh, Debmalya, et al.
Publicado: (2010)

The conserved mitochondrial gene distribution in relatives of Turritopsis nutricula, an immortal jellyfish
por: Devarapalli, Pratap, et al.
Publicado: (2014)

miRsig: a consensus-based network inference methodology to identify pan-cancer miRNA-miRNA interaction signatures
por: Nalluri, Joseph J., et al.
Publicado: (2017)

An In Silico Identification of Common Putative Vaccine Candidates against Treponema pallidum: A Reverse Vaccinology and Subtractive Genomics Based Approach
por: Kumar Jaiswal, Arun, et al.
Publicado: (2017)

HIV Protease Hinge Region Insertions at Codon 38 Affect Enzyme Kinetics, Conformational Stability and Dynamics
por: Sheik Ismail, Zaahida, et al.
Publicado: (2023)

Anticancer and Antiviral Properties of Cardiac Glycosides: A Review to Explore the Mechanism of Actions
por: Reddy, Dhanasekhar, et al.
Publicado: (2020)

New-Onset Saquinavir-Induced Diabetes
por: van Zoelen, Marieke A.D., et al.
Publicado: (2013)

Repurposing Saquinavir for Host-Directed Therapy to Control Mycobacterium Tuberculosis Infection
por: Pires, David, et al.
Publicado: (2021)

Novel aromatase inhibitors selection using induced fit docking and extra precision methods: Potential clinical use in ER-alpha-positive breast cancer
por: Kumavath, Ranjith, et al.
Publicado: (2016)

Tratamiento con saquinavir + zalcitabina + zidovudina vs saquinavir + lamivudina + zidovudina en pacientes con SIDA sin tratamiento previo
por: Jaimes Martínez, Marcos
Publicado: (2000)

In silico identification of essential proteins in Corynebacterium pseudotuberculosis based on protein-protein interaction networks
por: Folador, Edson Luiz, et al.
Publicado: (2016)

Saquinavir: From HIV to COVID-19 and Cancer Treatment
por: Pereira, Mariana, et al.
Publicado: (2022)

Comparative mangrove metagenome reveals global prevalence of heavy metals and antibiotic resistome across different ecosystems
por: Imchen, Madangchanok, et al.
Publicado: (2018)

Author Correction: Searching for signatures across microbial communities: Metagenomic analysis of soil samples from mangrove and other ecosystems
por: Imchen, Madangchanok, et al.
Publicado: (2018)

Searching for signatures across microbial communities: Metagenomic analysis of soil samples from mangrove and other ecosystems
por: Imchen, Madangchanok, et al.
Publicado: (2017)

Emergence of Cardiac Glycosides as Potential Drugs: Current and Future Scope for Cancer Therapeutics
por: Kumavath, Ranjith, et al.
Publicado: (2021)

Unexpected Hepatotoxicity of Rifampin and Saquinavir/Ritonavir in Healthy Male Volunteers
por: Schmitt, Christophe, et al.
Publicado: (2009)

Potential Hepatotoxicity of Efavirenz and Saquinavir/Ritonavir Coadministration in Healthy Volunteers
por: Jamois, Candice, et al.
Publicado: (2009)

A Case of Nephrotic Syndrome, Showing Evidence of Response to Saquinavir
por: Walters, Giles, et al.
Publicado: (2015)

Saquinavir plus methylprednisolone ameliorates experimental acute lung injury
por: Zhang, Guanghua, et al.
Publicado: (2018)

Saquinavir-Piperine Eutectic Mixture: Preparation, Characterization, and Dissolution Profile
por: Fandaruff, Cinira, et al.
Publicado: (2023)

Piper betel Compounds Piperidine, Eugenyl Acetate, and Chlorogenic Acid Are Broad-Spectrum Anti-Vibrio Compounds that Are Also Effective on MDR Strains of the Pathogen
por: Acosta-Smith, Erika, et al.
Publicado: (2019)

Simplifier: a web tool to eliminate redundant NGS contigs
por: Ramos, Rommel Thiago Jucá, et al.
Publicado: (2012)

Determining causal miRNAs and their signaling cascade in diseases using an influence diffusion model
por: Nalluri, Joseph J., et al.
Publicado: (2017)

In Silico Models: From Simple Networks to Complex Diseases
por: Barh, Debmalya, et al.
Publicado: (2014)

Structure-Based Design of Novel MAO-B Inhibitors: A Review
por: Mateev, Emilio, et al.
Publicado: (2023)

Enhancement of saquinavir absorption and accumulation through the formation of solid drug nanoparticles
por: Kigen, Gabriel, et al.
Publicado: (2018)

Artificial intelligence in precision health: from concept to applications
por: Barh, Debmalya
Publicado: (2020)

Liposomal Delivery of Saquinavir to Macrophages Overcomes Cathepsin Blockade by Mycobacterium tuberculosis and Helps Control the Phagosomal Replicative Niches
por: Pires, David, et al.
Publicado: (2023)

Evaluation of the Common Molecular Basis in Alzheimer’s and Parkinson’s Diseases
por: Rana, Pratip, et al.
Publicado: (2019)

Exploration of Nitrate Reductase Metabolic Pathway in Corynebacterium pseudotuberculosis
por: Almeida, Sintia, et al.
Publicado: (2017)

Evidence of episodic positive selection in Corynebacterium diphtheriae complex of species and its implementations in identification of drug and vaccine targets
por: Canário Viana, Marcus Vinicius, et al.
Publicado: (2022)

Two-Component Signal Transduction Systems of Pathogenic Bacteria As Targets for Antimicrobial Therapy: An Overview
por: Tiwari, Sandeep, et al.
Publicado: (2017)

Potential chimeric peptides to block the SARS-CoV-2 spike receptor-binding domain
por: Barh, Debmalya, et al.
Publicado: (2020)

Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis
por: Tommasi, Chiara, et al.
Publicado: (2011)

Novel intravaginal nanomedicine for the targeted delivery of saquinavir to CD4(+) immune cells
por: Yang, Sidi, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_72t5mjom53onsmabk9ieujt6eq