Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1

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Spinocerebellar ataxia type 1 (SCA1) is a paradigmatic neurodegenerative disease in that it is caused by a mutation in a broadly expressed protein, ATXN1; however, only select populations of cells degenerate. The interaction of polyglutamine-expanded ATXN1 with the transcriptional repressor CIC driv...

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Detalles Bibliográficos
Autores principales: Coffin, Stephanie L., Durham, Mark A., Nitschke, Larissa, Xhako, Eder, Brown, Amanda M., Revelli, Jean-Pierre, Gonzalez, Esmeralda Villavicencio, Lin, Tao, Handler, Hillary P., Dai, Yanwan, Trostle, Alexander J., Wan, Ying-Wooi, Liu, Zhandong, Sillitoe, Roy V., Orr, Harry T., Zoghbi, Huda Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9957872/
https://www.ncbi.nlm.nih.gov/pubmed/36577402
http://dx.doi.org/10.1016/j.neuron.2022.11.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9957872/
https://www.ncbi.nlm.nih.gov/pubmed/36577402
http://dx.doi.org/10.1016/j.neuron.2022.11.016

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