A novel mechanism underlying allosteric regulation of ADAMTS-13 revealed by hydrogen−deuterium exchange plus mass spectrometry

BACKGROUND: ADAMTS-13, a plasma metalloprotease, cleaves von Willebrand factor. ADAMTS-13 activity appears to be regulated through allosteric inhibition by its distal C-terminus. OBJECTIVES: The objective of this study was to better understand how domain–domain interactions may affect ADAMTS-13 conf...

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Detalles Bibliográficos
Autores principales: Pillai, Vikram G., Zheng, X. Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958085/
https://www.ncbi.nlm.nih.gov/pubmed/36852110
http://dx.doi.org/10.1016/j.rpth.2022.100012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958085/
https://www.ncbi.nlm.nih.gov/pubmed/36852110
http://dx.doi.org/10.1016/j.rpth.2022.100012

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