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A novel mechanism underlying allosteric regulation of ADAMTS-13 revealed by hydrogen−deuterium exchange plus mass spectrometry
BACKGROUND: ADAMTS-13, a plasma metalloprotease, cleaves von Willebrand factor. ADAMTS-13 activity appears to be regulated through allosteric inhibition by its distal C-terminus. OBJECTIVES: The objective of this study was to better understand how domain–domain interactions may affect ADAMTS-13 conf...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958085/ https://www.ncbi.nlm.nih.gov/pubmed/36852110 http://dx.doi.org/10.1016/j.rpth.2022.100012 |