Low-affinity CTCF binding drives transcriptional regulation whereas high-affinity binding encompasses architectural functions

CTCF is a DNA-binding protein which plays critical roles in chromatin structure organization and transcriptional regulation; however, little is known about the functional determinants of different CTCF-binding sites (CBS). Using a conditional mouse model, we have identified one set of CBSs that are...

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Detalles Bibliográficos
Autores principales: Marina-Zárate, Ester, Rodríguez-Ronchel, Ana, Gómez, Manuel J., Sánchez-Cabo, Fátima, Ramiro, Almudena R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958374/
https://www.ncbi.nlm.nih.gov/pubmed/36852270
http://dx.doi.org/10.1016/j.isci.2023.106106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958374/
https://www.ncbi.nlm.nih.gov/pubmed/36852270
http://dx.doi.org/10.1016/j.isci.2023.106106

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