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Low-affinity CTCF binding drives transcriptional regulation whereas high-affinity binding encompasses architectural functions
CTCF is a DNA-binding protein which plays critical roles in chromatin structure organization and transcriptional regulation; however, little is known about the functional determinants of different CTCF-binding sites (CBS). Using a conditional mouse model, we have identified one set of CBSs that are...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958374/ https://www.ncbi.nlm.nih.gov/pubmed/36852270 http://dx.doi.org/10.1016/j.isci.2023.106106 |