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Actin crosslinking by α-actinin averts viscous dissipation of myosin force transmission in stress fibers
Contractile force generated in actomyosin stress fibers (SFs) is transmitted along SFs to the extracellular matrix (ECM), which contributes to cell migration and sensing of ECM rigidity. In this study, we show that efficient force transmission along SFs relies on actin crosslinking by α-actinin. Upo...
Autores principales: | Katsuta, Hiroki, Okuda, Satoru, Nagayama, Kazuaki, Machiyama, Hiroaki, Kidoaki, Satoru, Kato, Masashi, Sokabe, Masahiro, Miyata, Takaki, Hirata, Hiroaki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9958379/ https://www.ncbi.nlm.nih.gov/pubmed/36852278 http://dx.doi.org/10.1016/j.isci.2023.106090 |
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